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国际心力衰竭治疗纵向观察医学实践评估注册研究(REPORT-HF):全球注册研究的原理与设计

International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): rationale for and design of a global registry.

作者信息

Filippatos Gerasimos, Khan Sadiya Sana, Ambrosy Andrew P, Cleland John G F, Collins Sean P, Lam Carolyn S P, Angermann Christiane E, Ertl Georg, Dahlström Ulf, Hu Dayi, Dickstein Kenneth, Perrone Sergio V, Ghadanfar Mathieu, Bermann Georgina, Noe Adele, Schweizer Anja, Maier Thomas, Gheorghiade Mihai

机构信息

Athens University Hospital Attikon, Athens, Greece.

出版信息

Eur J Heart Fail. 2015 May;17(5):527-33. doi: 10.1002/ejhf.262. Epub 2015 Mar 10.

Abstract

AIMS

The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide. REPORT-HF (International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure) is a global, prospective, and observational study designed to characterize patient trajectories longitudinally during and following an index hospitalization for HF.

METHODS

Data collection for the registry will be conducted at ∼300 sites located in ∼40 countries. Comprehensive data including demographics, clinical presentation, co-morbidities, treatment patterns, quality of life, in-hospital and post-discharge outcomes, and health utilization and costs will be collected. Enrolment of ∼20 000 adult patients hospitalized with new-onset (first diagnosis) HF or decompensation of chronic HF over a 3-year period is planned with subsequent 3 years follow-up.

PERSPECTIVE

The REPORT-HF registry will explore the clinical characteristics, management, and outcomes of HF worldwide. This global research programme may have implications for the formulation of public health policy and the design and conduct of international clinical trials.

摘要

目的

全球范围内,对于新发(首次诊断)心力衰竭(HF)或慢性HF失代偿患者住院时的临床特征、初始表现、治疗及预后情况了解甚少。REPORT-HF(评估心力衰竭治疗纵向观察医学实践的国际注册研究)是一项全球性、前瞻性观察性研究,旨在纵向描述HF指数住院期间及之后患者的病程轨迹。

方法

该注册研究的数据收集将在约40个国家的约300个地点进行。将收集包括人口统计学、临床表现、合并症、治疗模式、生活质量、住院及出院后结局以及卫生利用和费用等全面数据。计划在3年内纳入约20000例因新发(首次诊断)HF或慢性HF失代偿而住院的成年患者,并进行后续3年的随访。

观点

REPORT-HF注册研究将探索全球范围内HF的临床特征、治疗及预后情况。这一全球研究项目可能对公共卫生政策的制定以及国际临床试验的设计与开展具有启示意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df18/5024037/a059a7bc1c78/EJHF-17-527-g001.jpg

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