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锌补充剂对锌水平较低的澳大利亚老年人群的基因组稳定性生物标志物、抗氧化活性和锌转运蛋白基因有影响。

Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status.

作者信息

Sharif Razinah, Thomas Philip, Zalewski Peter, Fenech Michael

机构信息

Program of Nutritional Sciences, School of HealthCare Sciences, Faculty of Health Science, Universiti Kebangsaan Malaysia, Malaysia.

CSIRO Food and Nutrition, Adelaide, South Australia, Australia.

出版信息

Mol Nutr Food Res. 2015 Jun;59(6):1200-12. doi: 10.1002/mnfr.201400784. Epub 2015 May 13.

Abstract

SCOPE

An increased intake of Zinc (Zn) may reduce the risk of degenerative diseases but may prove to be toxic if taken in excess. This study aimed to investigate whether zinc carnosine supplement can improve Zn status, genome stability events, and Zn transporter gene expression in an elderly (65-85 years) South Australian cohort with low plasma Zn levels.

METHODS AND RESULTS

A 12-week placebo-controlled intervention trial was performed with 84 volunteers completing the study, (placebo, n = 42) and (Zn group, n = 42). Plasma Zn was significantly increased (p < 0.05) by 5.69% in the Zn supplemented group after 12 weeks. A significant (p < 0.05) decrease in the micronucleus frequency (-24.18%) was observed for the Zn supplemented cohort relative to baseline compared to the placebo group. Reductions of -7.09% for tail moment and -8.76% for tail intensity were observed for the Zn group (relative to baseline) (p < 0.05). Telomere base damage was found to be also significantly decreased in the Zn group (p < 0.05). Both MT1A and ZIP1 expression showed a significant increase in the Zn supplemented group (p < 0.05).

CONCLUSION

Zn supplementation may have a beneficial effect in an elderly population with low Zn levels by improving Zn status, antioxidant profile, and lowering DNA damage.

摘要

范围

锌(Zn)摄入量增加可能会降低退行性疾病的风险,但过量摄入可能会有毒性。本研究旨在调查在南澳大利亚州血浆锌水平较低的老年(65 - 85岁)队列中,补充肌肽锌是否能改善锌状态、基因组稳定性事件以及锌转运蛋白基因表达。

方法与结果

对84名志愿者进行了一项为期12周的安慰剂对照干预试验,(安慰剂组,n = 42)和(锌组,n = 42)。12周后,补充锌组的血浆锌显著增加(p < 0.05),增幅为5.69%。与安慰剂组相比,补充锌队列相对于基线的微核频率显著降低(p < 0.05),降低了24.18%。锌组相对于基线的尾矩降低了7.09%,尾强度降低了8.76%(p < 0.05)。锌组的端粒碱基损伤也显著降低(p < 0.05)。补充锌组的MT1A和ZIP1表达均显著增加(p < 0.05)。

结论

补充锌可能通过改善锌状态、抗氧化状况以及降低DNA损伤,对锌水平较低的老年人群产生有益影响。

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