血小板活化因子受体拮抗剂银杏内酯B抑制结肠炎相关癌症中的肿瘤发生和血管生成。
PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer.
作者信息
Sun Lei, He Zhen, Ke Jia, Li Senmao, Wu Xianrui, Lian Lei, He Xiaowen, He Xiaosheng, Hu Jiancong, Zou Yifeng, Wu Xiaojian, Lan Ping
机构信息
Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
出版信息
Int J Clin Exp Pathol. 2015 Jan 1;8(1):432-40. eCollection 2015.
Abstract
Platelet activating factor (PAF), a potent pro-inflammatory phospholipid, has been found to trigger tumor growth and angiogenesis through its G-protein coupled receptor (PAFR). This study was aimed to investigate the potential role of PAF in azoxymethane (AOM)/dextran sulfate sodium (DSS) induced colitis-associated cancer (CAC), using PAFR antagonist Ginkgolide B (GKB). We found GKB up-regulated serum level of PAF-AH activity. As assessed by disease activity index (DAI), histological injury scores, leukocytes infiltration, and expression of pro-inflammatory cytokines, GKB ameliorated colonic inflammation and decreased tumor number and load in mice. GKB also decreased expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in tumor. These results suggest that PAFR antagonist might be a potential therapeutic strategy for CAC.
摘要
血小板活化因子（PAF）是一种强效促炎磷脂，已发现它可通过其G蛋白偶联受体（PAFR）触发肿瘤生长和血管生成。本研究旨在使用PAFR拮抗剂银杏内酯B（GKB）研究PAF在氧化偶氮甲烷（AOM）/葡聚糖硫酸钠（DSS）诱导的结肠炎相关癌（CAC）中的潜在作用。我们发现GKB上调了血清PAF-AH活性水平。通过疾病活动指数（DAI）、组织学损伤评分、白细胞浸润和促炎细胞因子表达评估，GKB改善了小鼠的结肠炎症，并减少了肿瘤数量和负荷。GKB还降低了肿瘤中血管内皮生长因子（VEGF）的表达和微血管密度（MVD）。这些结果表明，PAFR拮抗剂可能是CAC的一种潜在治疗策略。
相似文献
1
PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer.血小板活化因子受体拮抗剂银杏内酯B抑制结肠炎相关癌症中的肿瘤发生和血管生成。
Int J Clin Exp Pathol. 2015 Jan 1;8(1):432-40. eCollection 2015.
2
Inhibitory effects of the platelet-activating factor receptor antagonists, CV-3988 and Ginkgolide B, on alkali burn-induced corneal neovascularization.血小板活化因子受体拮抗剂CV-3988和银杏内酯B对碱烧伤诱导的角膜新生血管形成的抑制作用。
Cutan Ocul Toxicol. 2015 Mar;34(1):53-60. doi: 10.3109/15569527.2014.903573. Epub 2014 Apr 22.
3
Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa.银杏内酯B对树鼩脑血栓形成后缺血神经元线粒体呼吸的改善作用
Chin Med J (Engl). 2007 Sep 5;120(17):1529-33.
4
Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists.7-取代银杏内酯衍生物的制备：强效血小板活化因子（PAF）受体拮抗剂。
J Med Chem. 2003 Feb 13;46(4):601-8. doi: 10.1021/jm0203985.
5
[Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation].银杏内酯B对慢性炎症中血管生成的抑制作用
Yao Xue Xue Bao. 2005 Apr;40(4):311-5.
6
Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF).缺乏血小板活化因子（PAF）受体的小鼠中的肿瘤生长、血管生成和炎症
Life Sci. 2007 Jun 27;81(3):210-7. doi: 10.1016/j.lfs.2007.05.003. Epub 2007 May 21.
7
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.银杏内酯 B 对大脑中动脉阻塞大鼠纹状体细胞外氨基酸的影响。
J Ethnopharmacol. 2011 Jun 14;136(1):117-22. doi: 10.1016/j.jep.2011.04.027. Epub 2011 Apr 16.
8
PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus.血小板活化因子拮抗剂银杏内酯B可减轻大鼠脑海马区缺血后的神经元损伤。
J Cereb Blood Flow Metab. 1990 Jan;10(1):133-5. doi: 10.1038/jcbfm.1990.17.
9
Murine colitis treated with multitargeted tyrosine kinase inhibitors.用多靶点酪氨酸激酶抑制剂治疗的小鼠结肠炎
J Surg Res. 2016 Feb;200(2):501-7. doi: 10.1016/j.jss.2015.09.023. Epub 2015 Sep 28.
10
Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.血小板激活因子在氟尿嘧啶诱导的小鼠肠道黏膜炎发病机制中的作用。
Cancer Chemother Pharmacol. 2011 Sep;68(3):713-20. doi: 10.1007/s00280-010-1540-5. Epub 2010 Dec 14.
引用本文的文献
1
Natural medicines target tumor vascular microenvironment to inhibit tumor.天然药物靶向肿瘤血管微环境以抑制肿瘤。
Genes Dis. 2025 Apr 8;12(6):101623. doi: 10.1016/j.gendis.2025.101623. eCollection 2025 Nov.
2
The Role of Herb-Partitioned Moxibustion in the Angiogenesis of Colitis-Associated Cancer in Rats.中药隔物灸对大鼠结肠炎相关癌血管生成的作用
J Inflamm Res. 2025 May 23;18:6623-6639. doi: 10.2147/JIR.S518214. eCollection 2025.
3
Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway.银杏内酯B通过AKT/mTOR信号通路抑制胃癌细胞的上皮-间质转化并促进细胞焦亡
Drug Des Devel Ther. 2025 Apr 2;19:2491-2502. doi: 10.2147/DDDT.S485240. eCollection 2025.
4
Impact of targeting the platelet-activating factor and its receptor in cancer treatment.靶向血小板活化因子及其受体在癌症治疗中的作用
Mil Med Res. 2025 Mar 4;12(1):10. doi: 10.1186/s40779-025-00597-0.
5
The Potential of as a Source of Biologically Active Compounds-A Review of the Recent Literature and Patents.作为生物活性化合物来源的潜力——对近期文献和专利的综述。
Molecules. 2023 May 9;28(10):3993. doi: 10.3390/molecules28103993.
6
Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer.PAFAH1B在泛癌中的预后及免疫作用的综合分析
Front Mol Biosci. 2022 Feb 3;8:799497. doi: 10.3389/fmolb.2021.799497. eCollection 2021.
7
Amide Derivatives of Ginkgolide B and Their Inhibitory Effects on PAF-Induced Platelet Aggregation.银杏内酯B的酰胺衍生物及其对血小板活化因子诱导的血小板聚集的抑制作用。
ACS Omega. 2021 Aug 24;6(35):22497-22503. doi: 10.1021/acsomega.1c01682. eCollection 2021 Sep 7.
8
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.从植物源萜类内酯骨架中开发潜在的抗肿瘤药物。
J Med Chem. 2020 Dec 24;63(24):15410-15448. doi: 10.1021/acs.jmedchem.0c01449. Epub 2020 Dec 8.
9
Cytotoxic effect of kernel extract on HCT116 and A2058 cancer cell lines.核提取物对HCT116和A2058癌细胞系的细胞毒性作用。
Heliyon. 2020 Sep 19;6(9):e04941. doi: 10.1016/j.heliyon.2020.e04941. eCollection 2020 Sep.
10
Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures.银杏内酯在神经疾病炎症免疫反应中的作用：当前文献综述
Front Syst Neurosci. 2020 Jul 31;14:45. doi: 10.3389/fnsys.2020.00045. eCollection 2020.
本文引用的文献
1
Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis.中性粒细胞浸润通过激活白细胞介素-1（IL-1）/白细胞介素-6轴促进结肠炎相关的肿瘤发生。
Mucosal Immunol. 2014 Sep;7(5):1106-15. doi: 10.1038/mi.2013.126. Epub 2014 Jan 15.
2
Overview of molecular pathways in inflammatory bowel disease associated with colorectal cancer development.炎症性肠病相关结直肠癌发生的分子途径概述。
Eur J Gastroenterol Hepatol. 2013 Mar;25(3):271-81. doi: 10.1097/MEG.0b013e32835b5803.
3
Current management of inflammatory bowel disease and colorectal cancer.炎症性肠病和结直肠癌的当前管理
Gastrointest Cancer Res. 2011 Mar;4(2):53-61.
4
Mechanisms of platelet-activating factor-induced enhancement of VEGF expression.血小板活化因子诱导血管内皮生长因子表达增强的机制。
Cell Physiol Biochem. 2011;27(1):55-62. doi: 10.1159/000325205. Epub 2011 Feb 11.
5
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.VEGF 受体信号通路将炎症与结肠炎相关癌症的肿瘤发生联系起来。
J Exp Med. 2010 Dec 20;207(13):2855-68. doi: 10.1084/jem.20100438. Epub 2010 Nov 22.
6
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.新型鞘氨醇激酶小分子抑制剂抑制小鼠结肠炎相关性结肠癌。
Carcinogenesis. 2010 Oct;31(10):1787-93. doi: 10.1093/carcin/bgq158. Epub 2010 Aug 5.
7
Inflammation and colon cancer.炎症与结肠癌。
Gastroenterology. 2010 Jun;138(6):2101-2114.e5. doi: 10.1053/j.gastro.2010.01.058.
8
The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses.血小板激活因子（PAF）在全身炎症反应中的信号级联。
Biochimie. 2010 Jun;92(6):692-7. doi: 10.1016/j.biochi.2010.02.011. Epub 2010 Feb 16.
9
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model.由黏膜固有层巨噬细胞衍生的 IL-6/可溶性 IL-6 受体诱导的结肠上皮细胞中 IL-6 转导信号在小鼠模型中结肠炎相关癌前病变发展中的重要作用。
J Immunol. 2010 Feb 1;184(3):1543-51. doi: 10.4049/jimmunol.0801217. Epub 2009 Dec 30.
10
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.白细胞介素-6（IL-6）和信号转导及转录激活因子3（Stat3）是肠道上皮细胞存活和结肠炎相关癌症发生所必需的。
Cancer Cell. 2009 Feb 3;15(2):103-13. doi: 10.1016/j.ccr.2009.01.001.
Zotero 插件