Flotillin-2的高表达与宫颈癌患者较差的临床生存率相关。
High expression of flotillin-2 is associated with poor clinical survival in cervical carcinoma.
作者信息
Liu Yaqiong, Lin Li, Huang Zijian, Ji Bing, Mei Shanshan, Lin Ying, Shen Zhuanxing
机构信息
Department of Obstetrics and Gynecology, Guangzhou Women and Children Medical Center, Guangzhou Medical University Affiliated Women and Children Medical Center Guangzhou 510120, China.
Department of Obstetrics and Gynecology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Shenzhen 518000, China.
出版信息
Int J Clin Exp Pathol. 2015 Jan 1;8(1):622-8. eCollection 2015.
AIMS
To investigate the expression and clinical significance of flotillin-2 (FLOT2) in cervical cancer (CC).
METHODS
We examined FLOT2 mRNA levels in 10 pairs of cervical cancer and adjacent normal tissues. Immunohistochemistry was performed to analyze FLOT2 protein expression in 115 archived cervical cancer samples. The association between FLOT2 levels, clinicopathologic factors and prognosis was analyzed statistically as well.
RESULTS
The cancer tissues of CC patients had clearly increased expression of FLOT2 at mRNA level as compared to adjacent nontumorous tissues. Survival analysis of CC patients indicated that FLOT2 expression was significantly associated with poor overall and local recurrence-free survival (P = 0.025 and P = 0.028, respectively). Moreover, FLOT2 expression was significantly correlated with clinical stage, tumor differentiation, and lymph nodes metastasis. Multivariate analysis revealed that FLOT2 expression was an independent prognostic factor for overall survival in CC patients.
CONCLUSION
FLOT2 may serve as an oncogene in the development of CC, and may serve as a clinicopathologic biomarker for prognosis in CC patients.
目的
探讨浮舰蛋白-2（FLOT2）在宫颈癌（CC）中的表达及临床意义。
方法
检测10对宫颈癌组织及癌旁正常组织中FLOT2 mRNA水平。采用免疫组织化学方法分析115例存档宫颈癌样本中FLOT2蛋白表达情况。同时对FLOT2水平、临床病理因素与预后的相关性进行统计学分析。
结果
与癌旁非肿瘤组织相比，CC患者癌组织中FLOT2在mRNA水平的表达明显增加。CC患者生存分析表明，FLOT2表达与总体生存及局部无复发生存显著相关（分别为P = 0.025和P = 0.028）。此外，FLOT2表达与临床分期、肿瘤分化及淋巴结转移显著相关。多因素分析显示，FLOT2表达是CC患者总体生存的独立预后因素。
结论
FLOT2可能在CC发生发展中作为癌基因发挥作用，并且可作为CC患者预后的临床病理生物标志物。
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