ROR2的上调与宫颈癌的不良预后和肿瘤进展相关。
Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer.
作者信息
Sun Bo, Ye Xiufeng, Lin Li, Shen Mei, Jiang Taotao
机构信息
Department of Obstetrics and Gynecology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Shenzhen 518035, China.
Department of Obstetrics and Gynecology, Anhui Medical University Hefei 230032, China.
出版信息
Int J Clin Exp Pathol. 2015 Jan 1;8(1):856-61. eCollection 2015.
AIMS
To investigate the clinical significance of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in cervical cancer.
METHODS
We examined ROR2 levels in 8 pairs of surgically resected cervical cancer and adjacent normal cervical tissues by real-time PCR. Moreover, we performed immunohistochemistry to examine ROR2 expression in 94 paraffin-embedded cervical cancer samples and analyzed the association between ROR2 expression, clinicopathologic factors and prognosis.
RESULTS
ROR2 expression was up-regulated in cervical cancer tissues compared with adjacent normal cervix. In paraffin-embedded cervical cancer samples, high expression of ROR2 was shown in 40 (42.6%) of 94 cases, also, it was significantly associated with tumor stage (P = 0.018) and lymph nodes metastasis (P = 0.013). Moreover, survival analysis showed that ROR2 expression was an independent prognostic factor of poor overall and recurrent free survival (P = 0.045 and 0.001, respectively).
CONCLUSION
These results indicate that ROR2 is significantly correlated with cancer progression and poor prognosis in cervical cancer.
目的
探讨受体酪氨酸激酶样孤儿受体2（ROR2）在宫颈癌中的临床意义。
方法
我们通过实时PCR检测了8对手术切除的宫颈癌组织及相邻正常宫颈组织中的ROR2水平。此外，我们采用免疫组织化学方法检测了94例石蜡包埋的宫颈癌样本中ROR2的表达情况，并分析了ROR2表达与临床病理因素及预后之间的关系。
结果
与相邻正常宫颈相比，宫颈癌组织中ROR2表达上调。在石蜡包埋的宫颈癌样本中，94例中有40例（42.6%）显示ROR2高表达，且其与肿瘤分期（P = 0.018）和淋巴结转移（P = 0.）显著相关。此外，生存分析表明ROR2表达是总体生存率和无复发生存率差的独立预后因素（分别为P = 0.045和0.001）。
结论
这些结果表明ROR2与宫颈癌的癌症进展和不良预后显著相关。 013
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