Calmettes C
INSERM, U. 113, CHU St-Antoine, Paris, France.
Horm Res. 1989;32(1-3):41-6. doi: 10.1159/000181241.
Medullary thyroid carcinoma (MTC) is a particularly interesting model of gene expression in cancer. As a matter of fact, it is remarkable from many points of view: it occurs in two forms: (1) MTC only or part of a multiple endocrine neoplasia II (MEN II), and (2) it is sporadic or inherited and benefits from a specific and sensible marker, calcitonin; the gene responsible for the hereditary form is localized on chromosome 10. Taking into account clinical, biological, genealogical and epidemiological features of the disease as supporting one another, a French collective study has been initiated; preliminary analysis of data allows to conclude on the value of such national collaboration for early diagnosis, prognosis and estimation of the incidence of the disease.
甲状腺髓样癌（MTC）是癌症中一个特别有趣的基因表达模型。事实上，它从多个角度来看都很显著：它以两种形式出现：（1）仅为MTC或作为多发性内分泌腺瘤病II型（MEN II）的一部分，以及（2）它是散发性的或遗传性的，并且受益于一种特定且灵敏的标志物——降钙素；导致遗传性形式的基因定位于10号染色体。考虑到该疾病临床、生物学、系谱学和流行病学特征相互支持，一项法国的联合研究已经启动；对数据的初步分析使得能够就这种全国性合作对于该疾病的早期诊断、预后和发病率评估的价值得出结论。
