Chen Qian, Gu Yonghong, Liu Binghui
Department of Pathology, The Third Xiangya Hospital of The Central South University Changsha, Hunan, China.
Int J Clin Exp Pathol. 2015 Jan 1;8(1):1007-12. eCollection 2015.
Kidney mucinous tubular and spindle cell carcinoma (MTSpCC) is a rare renal low-grade pleomorphic epithelial neoplasm featured by tubular and spindle cells with a relatively indolent behavior. This study was designed to clinicopathologically characterize two cases of kidney MTSpCC. Similar to other tumors, the data showed the diagnosis of MTSpCC relies on histological examination. Tumor cells stained strongly for CK19, CK20, and CK7 within the epithelioid component. Whereas evaluating MTSpCC clinically showed no specific symptoms, analyzing MTSpCC microscopically showed multiple elongated tubular branches of tumor cells that are closely arranged in cord-like manner under lightly stained myxoid stroma. MTSpCC also has the spindle cell area; the single tumor cell is small and nucleus round or oval. Immunohistochemical analysis of cytokeratins, electron microscopy, or genetic tests all improves the diagnosis.
肾黏液性管状和梭形细胞癌（MTSpCC）是一种罕见的肾脏低级别多形性上皮性肿瘤，其特征为管状和梭形细胞，行为相对惰性。本研究旨在对两例肾MTSpCC进行临床病理特征分析。与其他肿瘤相似，数据显示MTSpCC的诊断依赖于组织学检查。肿瘤细胞在上皮样成分中对CK19、CK20和CK7呈强阳性染色。临床评估MTSpCC时无特异性症状，而显微镜下分析MTSpCC可见多个细长的肿瘤细胞管状分支，在淡染的黏液样基质中呈条索状紧密排列。MTSpCC也有梭形细胞区域；单个肿瘤细胞小，核圆形或椭圆形。细胞角蛋白的免疫组织化学分析、电子显微镜检查或基因检测均有助于诊断。
