无麸质饮食能保护患有乳糜泻的儿童免受低骨密度的影响吗？
Does gluten-free diet protect children with celiac disease from low bone density?
作者信息
Usta Merve, Urganci Nafiye
机构信息
Department of Pediatric Gastroenterology, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
出版信息
Iran J Pediatr. 2014 Aug;24(4):429-34. Epub 2014 Jul 4.
OBJECTIVE
We aimed to assess the effect and duration of gluten-free diet on bone health in children with celiac disease in our study.
METHODS
Sixty three patients with celiac disease (CD) formed the study group. They were divided into two subgroups according to their dietary compliance. Bone mineral density (BMD) values of the patients at two and five years of gluten-free diet (GFD) were determined. Findings : The relationship between BMD and compliance to GFD was found to be statistically significant (P<0.01). BMD z-scores were increased (0.12±0.15 and 0.10±0.14 units respectively) (P<0.01). The patients in group 1 and 2 had mean -1.18±0.83 and -2.06±0.73 z-scores in the first DXA. In the second DXA, these values were -1.10±0.73 and-1.94±0.93 respectively.
CONCLUSION
Dietary compliance is important for bone health, and the time needed to normalize the BMD is not known. Patients with positive anti-endomysium antibody (EMA), poor dietary history and history of bone pain should be evaluated with DXA during follow-up.
目的
在我们的研究中，旨在评估无麸质饮食对乳糜泻患儿骨骼健康的影响及持续时间。
方法
63例乳糜泻（CD）患者组成研究组。根据饮食依从性将他们分为两个亚组。测定患者在无麸质饮食（GFD）两年和五年时的骨密度（BMD）值。结果：发现BMD与GFD依从性之间的关系具有统计学意义（P<0.01）。BMD z评分增加（分别为0.12±0.15和0.10±0.14个单位）（P<0.01）。在第一次双能X线吸收法（DXA）检查中，第1组和第2组患者的平均z评分为-1.18±0.83和-2.06±0.73。在第二次DXA检查中，这些值分别为-1.10±0.73和-1.94±0.93。
结论
饮食依从性对骨骼健康很重要，且使BMD恢复正常所需的时间尚不清楚。随访期间，抗肌内膜抗体（EMA）阳性、饮食史不佳和有骨痛病史的患者应通过DXA进行评估。
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