小鼠9号染色体上低密度脂蛋白受体基因的连锁关系。

Linkage of the mouse LDL receptor gene on chromosome 9.

作者信息

Frank S L, Taylor B A, Lusis A J

机构信息

Department of Microbiology, University of California, Los Angeles 90024.

出版信息

Genomics. 1989 Oct;5(3):646-8. doi: 10.1016/0888-7543(89)90037-2.

DOI:10.1016/0888-7543(89)90037-2

PMID:2575592

Abstract

We identified restriction fragment length variants of the mouse low-density lipoprotein receptor gene and used these to map the gene, designated Ldlr, to the proximal region of chromosome 9. An interspecific backcross between strains MEV and CAST/Ei yielded the following gene order and distances in centimorgans: Ldlr-18.8 +/- 5.6-Apoa-4-7.3 +/- 3.5-Mpi-1-10.2 +/- 3.9-Emv-3 or dilute. Analysis of recombinant inbred strains also indicated that Ldlr is tightly linked to a previously unmapped retroviral marker, Xmmv-67.

摘要

我们鉴定出了小鼠低密度脂蛋白受体基因的限制性片段长度变异，并利用这些变异将该基因（命名为Ldlr）定位到9号染色体的近端区域。MEV和CAST/Ei品系之间的种间回交产生了以下基因顺序和以厘摩为单位的距离：Ldlr - 18.8 ± 5.6 - Apoa - 4 - 7.3 ± 3.5 - Mpi - 1 - 10.2 ± 3.9 - Emv - 3或dilute。重组近交系的分析也表明，Ldlr与一个先前未定位的逆转录病毒标记Xmmv - 67紧密连锁。