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艾滋病病毒治疗即预防研究:在十字路口选对道路。

HIV treatment-as-prevention research: taking the right road at the crossroads.

作者信息

Hayes Richard, Fidler Sarah, Cori Anne, Fraser Christophe, Floyd Sian, Ayles Helen, Beyers Nulda, El-Sadr Wafaa

机构信息

London School of Hygiene & Tropical Medicine, Department of Infectious Disease Epidemiology, London, United Kingdom.

Imperial College London, Department of Medicine, London, United Kingdom.

出版信息

PLoS Med. 2015 Mar 10;12(3):e1001800. doi: 10.1371/journal.pmed.1001800. eCollection 2015 Mar.

DOI:10.1371/journal.pmed.1001800
PMID:25756285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4355412/
Abstract

Reflecting on a Policy Forum article by Till Bärnighausen and colleagues, the HPTN 071 (PopART) Study Team consider ethical and study power concerns and the importance of the trial's future findings.

摘要

在反思蒂尔·贝恩豪森及其同事发表的一篇政策论坛文章时,HPTN 071(PopART)研究团队考虑了伦理和研究效力问题以及该试验未来研究结果的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4a/4355412/56e7886a4b06/pmed.1001800.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4a/4355412/56e7886a4b06/pmed.1001800.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4a/4355412/56e7886a4b06/pmed.1001800.g001.jpg

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本文引用的文献

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HIV treatment-as-prevention research at a crossroads.处于十字路口的HIV治疗即预防研究。
PLoS Med. 2014 Jun 3;11(6):e1001654. doi: 10.1371/journal.pmed.1001654. eCollection 2014 Jun.
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Transformation of HIV from pandemic to low-endemic levels: a public health approach to combination prevention.将 HIV 从大流行转变为低流行水平:综合预防的公共卫生方法。
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上海HIV阳性患者基线CD4细胞计数趋势及晚期开始抗逆转录病毒治疗的危险因素:一项回顾性横断面研究
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PLoS Med. 2015 Mar 10;12(3):e1001799. doi: 10.1371/journal.pmed.1001799. eCollection 2015 Mar.
HPTN 071(PopART):一项评估包含普遍检测和治疗的艾滋病综合预防干预对人群影响的整群随机试验的原理和设计 - 一项整群随机试验的研究方案。
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HPTN 071 (PopART): a cluster-randomized trial of the population impact of an HIV combination prevention intervention including universal testing and treatment: mathematical model.HPTN 071(PopART):一项关于包括普遍检测和治疗在内的HIV联合预防干预措施对人群影响的整群随机试验:数学模型
PLoS One. 2014 Jan 15;9(1):e84511. doi: 10.1371/journal.pone.0084511. eCollection 2014.
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The HIV care cascade through time.随时间推移的艾滋病病毒治疗连续过程。
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Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a cluster randomised controlled trial.评价即刻启动与按照世界卫生组织(WHO)建议启动抗逆转录病毒治疗对艾滋病病毒(HIV)发病率影响的研究:南非夸祖鲁-纳塔尔省 Hlabisa 分区内的 ANRS 12249 TasP(治疗即预防)试验:一项整群随机对照试验的研究方案。
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J Infect Dis. 2013 Jul 15;208(2):189-91. doi: 10.1093/infdis/jit154. Epub 2013 Apr 9.
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Curr HIV/AIDS Rep. 2013 Jun;10(2):152-8. doi: 10.1007/s11904-013-0152-1.
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AIDS. 2013 Jan 28;27(3):447-58. doi: 10.1097/QAD.0b013e32835ca2dd.
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The HIV care continuum: no partial credit given.艾滋病病毒护理连续统一体:不予部分计分。
AIDS. 2012 Sep 10;26(14):1735-8. doi: 10.1097/QAD.0b013e328355d67b.