Kyhl Henriette Boye, Jensen Tina Kold, Barington Torben, Buhl Susanne, Norberg Lene Annette, Jørgensen Jan Stener, Jensen Ditlev Frank Granhøj, Christesen Henrik Thybo, Lamont Ronald F, Husby Steffen
Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense C, Denmark.
Paediatr Perinat Epidemiol. 2015 May;29(3):250-8. doi: 10.1111/ppe.12183. Epub 2015 Mar 10.
The importance of the environment on the development of the fetus and infant throughout early life is increasingly recognised. To study such effects, biological samples and accurate data records are required. Based on multiple data collection from a healthy pregnant population, the Odense Childhood Cohort (OCC) study aims to provide new information about the environmental impact on child health by sequential follow-up to 18 years of age among children born between 2010 and 2012.
A total of 2874 of 6707 pregnancies (43%) were recruited between January 2010 and December 2012. Three hundred seventy-four have since left the study, leaving 2500 active families. The non-participants act as controls contributing data through local registries. Biological material, questionnaires, and registry data were compiled. Anthropometric data and other physical data were collected.
Two thousand five hundred families actively participated in the study with 2549 children. Sixty-four per cent of the fathers and 60% and 58% of the mothers, respectively, donated a blood sample at 10 and 28 weeks of gestation. On average, 69% completed questionnaires, 78% of the children were regularly examined, and had a blood sample taken (46%). The participating pregnant women differed from the non-participants in several respects: age, body mass index, smoking, parity, education, and ethnicity. The infants were comparable with respect to gender and mode of delivery.
The OCC provides material for in-depth analysis of environmental and genetic factors that are important for child health and disease. Registry data from non-participating women and infants are available which ensures a high degree of comparable data.
环境对胎儿和婴儿早期发育的重要性日益受到认可。为研究此类影响，需要生物样本和准确的数据记录。基于对健康孕妇群体的多次数据收集，欧登塞儿童队列（OCC）研究旨在通过对2010年至2012年出生儿童进行连续追踪至18岁，提供有关环境对儿童健康影响的新信息。
2010年1月至2012年12月期间，在6707例妊娠中招募了2874例（43%）。此后有374例退出研究，剩余2500个活跃家庭。未参与者作为对照，通过当地登记处提供数据。收集了生物材料、问卷和登记数据。收集了人体测量数据和其他身体数据。
2500个家庭积极参与研究，共有2549名儿童。分别有64%的父亲以及60%和58%的母亲在妊娠10周和28周时捐献了血样。平均而言，69%的家庭完成了问卷，78%的儿童接受了定期检查并采集了血样（46%）。参与研究的孕妇在几个方面与未参与者不同：年龄、体重指数、吸烟情况、产次、教育程度和种族。婴儿在性别和分娩方式方面具有可比性。
OCC提供了材料，可用于深入分析对儿童健康和疾病至关重要的环境和遗传因素。可获得未参与研究的妇女和婴儿的登记数据，这确保了数据具有高度可比性。
