Yu Hee Tae, Oh Jaewon, Chang Hyuk-Jae, Lee Sang-Hak, Shin Eui-Cheol, Park Sungha
aLaboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon bCardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Coron Artery Dis. 2015 Jun;26(4):317-21. doi: 10.1097/MCA.0000000000000236.
T-cell-mediated immune responses play important roles in the progression of atherosclerotic disease. Studies have linked various inflammatory biomarkers with the burden of coronary artery calcification, but the significance of T-cell-specific chemokines in coronary artery calcification has not been confirmed. We aimed to examine the association between serum levels of the monokine induced by gamma interferon (MIG) and the coronary artery calcium score (CACS).
We enrolled 456 individuals (285 men, 66.5±5.8 years) who were registered in the Mapo-gu public health center cohort. We selected 228 individuals with a CACS of more than 100 and 228 age-matched and sex-matched individuals with a CACS of less than 100. All participants underwent coronary computed tomography for CACS measuring. Clinical and laboratory variables including serum MIG levels were analyzed at the time of enrollment.
The serum level of MIG was significantly higher in participants with a CACS of more than 100 (152.1±119.1 vs. 130.3±112.9, P=0.046). Serum MIG levels correlated significantly with CACS (r=0.113, P=0.016), and higher levels of MIG were associated with severe plaque burden (CACS>400, P=0.025). Multiple linear regression analysis showed that serum MIG levels were associated independently with CACS after controlling for confounding factors and medications (β=0.114, P=0.026).
Serum MIG levels were associated independently with CACS after adjusting for traditional cardiovascular risk factors. These findings suggest that MIG may be used as a novel biomarker for T-cell inflammation and atherosclerotic plaque burden in humans.
T细胞介导的免疫反应在动脉粥样硬化疾病进展中起重要作用。研究已将多种炎症生物标志物与冠状动脉钙化负担联系起来，但T细胞特异性趋化因子在冠状动脉钙化中的意义尚未得到证实。我们旨在研究γ干扰素诱导的单核细胞趋化蛋白（MIG）血清水平与冠状动脉钙化评分（CACS）之间的关联。
我们纳入了麻浦区公共卫生中心队列登记的456名个体（285名男性，年龄66.5±5.8岁）。我们选择了228名CACS大于100的个体以及228名年龄和性别匹配、CACS小于100的个体。所有参与者均接受冠状动脉计算机断层扫描以测量CACS。在入组时分析了包括血清MIG水平在内的临床和实验室变量。
CACS大于100的参与者血清MIG水平显著更高（152.1±119.1 vs. 130.3±112.9，P=0.046）。血清MIG水平与CACS显著相关（r=0.113，P=0.016），且MIG水平较高与严重斑块负担相关（CACS>400，P=0.025）。多元线性回归分析显示，在控制混杂因素和药物后，血清MIG水平与CACS独立相关（β=0.114，P=0.026）。
在调整传统心血管危险因素后，血清MIG水平与CACS独立相关。这些发现表明，MIG可能用作人类T细胞炎症和动脉粥样硬化斑块负担的新型生物标志物。
