Owen Joshua L, Word Andrew P, Vandergriff Travis, Desai Seemal R
University of Texas Southwestern Medical Center.
Dermatol Online J. 2014 Nov 23;21(2):13030/qt1rh2t3hg.
Plaque-like cutaneous mucinosis (PCM) is a rare disorder of dermal mucin deposition. Some patients with PCM will be found to have an associated malignancy. We report the case of a 72-year-old man presenting with new onset pruritic, waxy-appearing erythematous and skin-colored papules and nodules coalescing into plaques on his shoulder, scalp, and forehead. Skin biopsy revealed cutaneous mucinosis. Despite conservative treatment, his skin lesions progressed, and he was found to have an occult malignancy of pancreatobiliary origin. After several months of chemotherapy, his skin lesions showed progressive improvement. To our knowledge, this is the third reported case of paraneoplastic PCM and the first reported to occur in association with underlying adenocarcinoma of pancreatobiliary origin. PCM may occasionally represent a paraneoplastic dermatosis. This case highlights the importance of a search for occult malignancy in such patients.
斑块状皮肤粘蛋白沉积症（PCM）是一种罕见的真皮粘蛋白沉积性疾病。部分PCM患者会被发现伴有恶性肿瘤。我们报告一例72岁男性病例，其肩部、头皮和前额出现新发瘙痒性、蜡样外观的红斑及肤色丘疹和结节，并融合成斑块。皮肤活检显示为皮肤粘蛋白沉积症。尽管进行了保守治疗，其皮肤病变仍进展，随后发现他患有隐匿性胰胆管源性恶性肿瘤。经过数月化疗，其皮肤病变逐渐改善。据我们所知，这是第三例副肿瘤性PCM报道病例，也是首例与胰胆管源性腺癌相关的报道病例。PCM偶尔可能代表一种副肿瘤性皮肤病。该病例凸显了对此类患者寻找隐匿性恶性肿瘤的重要性。
