Bregvadze Kakha, Mekokishvili Lally
Department of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia.
Petre Shotadze Tbilisi Medical Academy, Tbilisi, Georgia.
SAGE Open Med Case Rep. 2024 Oct 11;12:2050313X241290121. doi: 10.1177/2050313X241290121. eCollection 2024.
Plaque-like cutaneous mucinosis (PCM) is a rare atypical subtype of Lichen myxedematosus, characterized by hyperpigmented plaques typically found on the midline trunk. We report the case of a 26-year-old woman with a 1-year history of painful, pruritic, hyperpigmented plaques over her spine. Physical examination revealed soft plaques in the midline of the back, and histopathology showed dermal mucin deposition, consistent with PCM. The presented case is notable as the first reported instance of PCM presenting with lesional pain. We propose that mechanical stress, likely due to repeated friction at the site of spinous processes, contributed to the development of pain. The fact that pain lessened after the use of a lumbar support pillow and gaining weight supports our hypothesis. Our case demonstrates the importance of considering PCM in the differential diagnosis of hyperpigmented plaques and highlights the need for further research to elucidate its underlying pathogenesis and optimize treatment strategies.
斑块状皮肤粘蛋白病（PCM）是黏液性苔藓的一种罕见非典型亚型，其特征为通常出现在躯干中线的色素沉着斑块。我们报告一例26岁女性病例，其脊柱部位出现疼痛、瘙痒的色素沉着斑块已有1年病史。体格检查发现背部中线处有柔软斑块，组织病理学显示真皮粘蛋白沉积，符合PCM表现。该病例值得注意之处在于，它是首例报告的伴有皮损疼痛的PCM病例。我们认为，机械性应力可能是由于棘突部位反复摩擦所致，这促使了疼痛的发生。使用腰部支撑枕并体重增加后疼痛减轻这一事实支持了我们的假设。我们的病例表明，在色素沉着斑块的鉴别诊断中考虑PCM的重要性，并强调需要进一步研究以阐明其潜在发病机制并优化治疗策略。
