Gold Heidi L, Wang Iris, Meehan Shane, Sanchez Miguel, Smith Gideon P
Sackler School of Medicine.
Dermatol Online J. 2014 Dec 13;21(2):13030/qt4xf2m886.
Silicone injections have been used for cosmetic soft tissue augmentation for over five decades with documented consequences both systemic and dermatologic. We present a case of extensive filler migration causing bilateral lower extremity woody induration in a 53 year old Hispanic woman. She presented with a multi-year history of progressive joint stiffening at the knees, accompanied by induration and pain of the bilateral lower extremities. The patient had received two injections of an unknown substance placed into her bilateral gluteals 11 years prior. MRI indicated an infiltrative process of both lower extremities and pathology was consistent with migration of injected tissue augmentation material, most likely silicone. Due to the extent of involvement the patient was started on a trial of doxycycline 100 mg PO BID.
五十多年来，硅胶注射一直被用于美容性软组织填充，其全身性和皮肤方面的后果都有文献记载。我们报告一例53岁西班牙裔女性因大量填充剂迁移导致双侧下肢木样硬结的病例。她有多年双膝关节进行性僵硬病史，伴有双侧下肢硬结和疼痛。该患者11年前曾在双侧臀部分两次注射了一种不明物质。磁共振成像显示双下肢有浸润性病变，病理检查结果与注射用组织填充材料（很可能是硅胶）的迁移相符。鉴于受累范围，患者开始试用强力霉素，口服，每次100毫克，每日两次。
