Bannach Ster Vogel, Teixeira Francisco Bruno, Fernandes Luanna Melo Pereira, Ferreira Railson Oliveira, Santana Luana Nazaré da Silva, Fontes-Júnior Enéas Andrade, Oliveira Gedeão Batista, Prediger Rui Daniel
Indian J Exp Biol. 2015 Feb;53(2):93-7.
Though there are literature indicating the bone loss due to alcohol consumption, studies on the association between ethanol consumption and periodontal breakdown in animals are either scarce or have provided conflicting results. Here, we investigated the effects of chronic alcohol exposure from adolescence to adulthood on the alveolar bone in rats. Wistar rats were exposed to ethanol (6.5 g/kg/day) in a solution of 22.5% (w/v) or distilled water (control) by gavage from 35 days of age (adolescent) until 90 days (adulthood). Evaluation of the bone loss was performed using scanning electronic microscopy, in which the distances between the cement-enamel junction and the alveolar bone crest from the palatal side of the first molar mandibular were measured. The measurements obtained were tabulated and analyzed using Student's t-test. Alcohol-treated group revealed greater bone loss in comparison to the control group. These findings indicate that heavy chronic alcohol exposure from adolescent to adulthood can induce alveolar bone loss in rats associated to absence of periodontitis.
尽管有文献表明饮酒会导致骨质流失，但关于乙醇摄入与动物牙周组织破坏之间关联的研究要么很少，要么结果相互矛盾。在此，我们研究了从青春期到成年期长期接触酒精对大鼠牙槽骨的影响。将Wistar大鼠从35日龄（青春期）至90日龄（成年期）通过灌胃给予22.5%（w/v）乙醇溶液（6.5 g/kg/天）或蒸馏水（对照组）。使用扫描电子显微镜评估骨质流失情况，测量下颌第一磨牙腭侧牙骨质-釉质界与牙槽嵴顶之间的距离。将获得的测量数据制成表格，并使用学生t检验进行分析。与对照组相比，酒精处理组显示出更大的骨质流失。这些发现表明，从青春期到成年期长期大量接触酒精可在无牙周炎的大鼠中诱导牙槽骨流失。
