Vacas María I, Amer Mariano, Chiarenza Ana P, Luchelli María A, Mandalunis Patricia M, Elverdin Juan C
Department of Biochemistry, Faculty of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
J Periodontol. 2008 Jun;79(6):1075-80. doi: 10.1902/jop.2008.070566.
The incidence of dry mouth and its public health impact are increasing as the result of a progressively larger, medicated older population and because chronic diseases, like periodontitis, are prevalent pathologies among elderly patients. Periodontitis and continuous remodeling and rebuilding alveolar processes greatly affect the margin of the alveolar bone, and there is evidence indicating the role of submandibular glands in the regulation of immune/inflammatory reactions. The purpose of this study was to assess the effect of submandibular-sublingual complex ablation (Sx) on alveolar bone loss in rats submitted or not to ligature-induced experimental periodontal disease (EP).
Wistar male rats were submitted to Sx or sham operations (day 0). Two weeks later, unilateral EP was induced on the right mandibular first molars for 7 days with the contralateral side serving as control. Bone loss at the level of the dental pieces was estimated by bone histomorphometry on mesio-distally oriented sections of the molars and by the determination on lingual and vestibular mandibular surfaces of the distances from the cemento-enamel junction to the alveolar crest.
Sx and EP significantly increased lingual and vestibular alveolar bone loss. Molars with EP exhibited greater lingual loss in Sx animals compared to those with the sham operation. EP induced similar interradicular bone loss in sham and Sx rats.
Sx has a deleterious effect on the periodontal tissues, particularly marginal alveolar bone, indicating the importance of the submandibular/sublingual glands in maintaining healthy periodontal conditions.
由于老年用药人口不断增加，以及诸如牙周炎等慢性疾病在老年患者中普遍存在，口干的发病率及其对公众健康的影响正在上升。牙周炎以及牙槽突的持续重塑和重建极大地影响牙槽骨边缘，并且有证据表明下颌下腺在免疫/炎症反应调节中发挥作用。本研究的目的是评估下颌下-舌下复合体切除（Sx）对患有或未患有结扎诱导的实验性牙周病（EP）的大鼠牙槽骨丢失的影响。
Wistar雄性大鼠在第0天接受Sx或假手术。两周后，在右侧下颌第一磨牙诱导单侧EP持续7天，对侧作为对照。通过对磨牙近远中向切片进行骨组织形态计量学以及通过测定下颌舌侧和前庭表面从牙骨质-釉质界到牙槽嵴的距离来估计牙片水平的骨丢失。
Sx和EP显著增加舌侧和前庭牙槽骨丢失。与假手术动物相比，患有EP的磨牙在接受Sx的动物中表现出更大的舌侧骨丢失。EP在假手术和接受Sx的大鼠中诱导了相似的根间骨丢失。
Sx对牙周组织，特别是牙槽嵴顶骨有有害影响，表明下颌下/舌下腺在维持健康牙周状况中的重要性。
