From the, Laboratory of Pharmacology of Inflammation and Behavior, (CdSFM, LYQ, IGdO, CCSdS), Faculty of Pharmacy, Institute of Health Science, Federal University of Pará, Belém, Pará, Brazil.
CNC-Center for Neurosciences and Cell Biology, (RAC), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Alcohol Clin Exp Res. 2021 Jan;45(1):56-63. doi: 10.1111/acer.14501. Epub 2020 Dec 22.
Alcohol (EtOH) intake during adolescence has become an important public health issue. Although the detrimental effects of EtOH intake on the musculoskeletal system are well known, only a few studies have investigated its impact on the stomatognathic system of adolescents. This study aimed to investigate the effect of EtOH binge drinking on the alveolar bone and the long-term consequences after abstinence.
Adolescent female Wistar rats (35 days old) were exposed to 4 cycles of EtOH binge drinking (3 g/kg/d; 3 days On-4 days Off) or distilled water (control group). Alveolar bone micromorphology and vertical bone distance were evaluated at 1, 30, and 60 days after that last EtOH intake through X-ray computed microtomography. The mineral:matrix ratio was assessed through Raman spectroscopy.
A decrease in both trabecular thickness and volume ratio, and an increase in trabecular separation were observed at the 1-day evaluation (immediate withdrawal). After 30 and 60 days, the alveolar bone parameters were found similar to control, except for the mineral:matrix ratio in the long-term abstinence.
EtOH binge drinking during adolescence results in alveolar bone damage that may persist in adulthood, even after abstinence.
青少年饮酒已成为一个重要的公共卫生问题。尽管乙醇摄入对骨骼肌肉系统的有害影响众所周知，但仅有少数研究调查了其对青少年口腔颌面部系统的影响。本研究旨在探讨乙醇 binge drinking 对牙槽骨的影响，以及戒酒后的长期后果。
35 天大的雌性 Wistar 大鼠接受 4 个周期的乙醇 binge drinking（3g/kg/d；3 天 ON-4 天 OFF）或蒸馏水（对照组）处理。在最后一次乙醇摄入后 1、30 和 60 天，通过 X 射线计算机微断层扫描评估牙槽骨微形态和垂直骨距离。通过拉曼光谱评估矿化基质比。
在即刻戒断时（1 天评估）观察到骨小梁厚度和体积比降低，以及骨小梁分离增加。30 和 60 天后，除了长期戒断时的矿化基质比之外，牙槽骨参数与对照组相似。
青少年时期的乙醇 binge drinking 会导致牙槽骨损伤，即使在戒酒后，这种损伤也可能持续到成年期。
