Bianco Paolo, Robey Pamela G
Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Development. 2015 Mar 15;142(6):1023-7. doi: 10.1242/dev.102210.
Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow organ. SSCs conjoin skeletal and hematopoietic physiology, and are a tool for understanding and ameliorating skeletal and hematopoietic disorders. Here and in the accompanying poster, we concisely discuss the biology of SSCs in the context of the development and postnatal physiology of skeletal lineages, to which their use in medicine must remain anchored.
骨骼干细胞（SSCs）存在于出生后的骨髓中，在特定的体内试验中可分化为软骨、骨、支持造血的基质和骨髓脂肪细胞。这些谱系在胚胎发育和出生后生长过程中按特定顺序出现，共同构成一个连续的解剖系统——骨-骨髓器官。SSCs将骨骼和造血生理联系起来，是理解和改善骨骼及造血疾病的工具。在这里以及随附的海报中，我们简要讨论了SSCs在骨骼谱系发育和出生后生理学背景下的生物学特性，医学应用必须以此为基础。
