骨骼干细胞
Skeletal stem cells.
作者信息
Bianco Paolo, Robey Pamela G
机构信息
Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
出版信息
Development. 2015 Mar 15;142(6):1023-7. doi: 10.1242/dev.102210.
Abstract
Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow organ. SSCs conjoin skeletal and hematopoietic physiology, and are a tool for understanding and ameliorating skeletal and hematopoietic disorders. Here and in the accompanying poster, we concisely discuss the biology of SSCs in the context of the development and postnatal physiology of skeletal lineages, to which their use in medicine must remain anchored.
摘要
骨骼干细胞（SSCs）存在于出生后的骨髓中，在特定的体内试验中可分化为软骨、骨、支持造血的基质和骨髓脂肪细胞。这些谱系在胚胎发育和出生后生长过程中按特定顺序出现，共同构成一个连续的解剖系统——骨-骨髓器官。SSCs将骨骼和造血生理联系起来，是理解和改善骨骼及造血疾病的工具。在这里以及随附的海报中，我们简要讨论了SSCs在骨骼谱系发育和出生后生理学背景下的生物学特性，医学应用必须以此为基础。
相似文献
1
Skeletal stem cells.骨骼干细胞
Development. 2015 Mar 15;142(6):1023-7. doi: 10.1242/dev.102210.
2
Identification and specification of the mouse skeletal stem cell.小鼠骨骼干细胞的鉴定与特性研究
Cell. 2015 Jan 15;160(1-2):285-98. doi: 10.1016/j.cell.2014.12.002.
3
Bone and the hematopoietic niche: a tale of two stem cells.骨与造血龛：两种干细胞的故事。
Blood. 2011 May 19;117(20):5281-8. doi: 10.1182/blood-2011-01-315069. Epub 2011 Mar 15.
4
Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury.骨膜骨骼干细胞在损伤后可迁移至骨髓并支持造血。
Elife. 2025 May 22;13:RP101714. doi: 10.7554/eLife.101714.
5
Skeletal Stem Cells for Bone Development and Repair: Diversity Matters.骨骼干细胞在骨骼发育和修复中的作用：多样性很重要。
Curr Osteoporos Rep. 2020 Jun;18(3):189-198. doi: 10.1007/s11914-020-00572-9.
6
Establishment of bone marrow and hematopoietic niches in vivo by reversion of chondrocyte differentiation of human bone marrow stromal cells.通过逆转人骨髓基质细胞的软骨细胞分化在体内建立骨髓和造血微环境。
Stem Cell Res. 2014 May;12(3):659-72. doi: 10.1016/j.scr.2014.01.006. Epub 2014 Feb 8.
7
Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells.骨、软骨和造血龛基质细胞的克隆前体细胞。
Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12643-8. doi: 10.1073/pnas.1310212110. Epub 2013 Jul 15.
8
C-KIT Expression Distinguishes Fetal from Postnatal Skeletal Progenitors.C-KIT 表达可区分胎儿和成体骨骼祖细胞。
Stem Cell Reports. 2020 Apr 14;14(4):614-630. doi: 10.1016/j.stemcr.2020.03.001. Epub 2020 Mar 26.
9
MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.MT1-MMP 和 II 型胶原特异性标记骨骼干细胞及其骨和软骨祖细胞。
J Bone Miner Res. 2009 Nov;24(11):1905-16. doi: 10.1359/jbmr.090510.
10
Aged skeletal stem cells generate an inflammatory degenerative niche.衰老的骨骼干细胞产生炎症性退行性龛位。
Nature. 2021 Sep;597(7875):256-262. doi: 10.1038/s41586-021-03795-7. Epub 2021 Aug 11.
引用本文的文献
1
Distinct stromal cell populations define the B-cell acute lymphoblastic leukemia microenvironment.不同的基质细胞群体界定了B细胞急性淋巴细胞白血病的微环境。
Leukemia. 2025 Aug 15. doi: 10.1038/s41375-025-02734-z.
2
Fibrous dysplasia/McCune-Albright syndrome: state-of-the-art advances, pathogenesis, and basic/translational research.纤维发育不良/麦库恩-奥尔布赖特综合征：最新进展、发病机制及基础/转化研究
Orphanet J Rare Dis. 2025 Aug 8;20(1):414. doi: 10.1186/s13023-025-03909-8.
3
p75 regulates postnatal skeletal development via NGF-responsive JNK signaling.p75通过NGF反应性JNK信号通路调节出生后骨骼发育。
Bone Rep. 2025 Jun 13;26:101854. doi: 10.1016/j.bonr.2025.101854. eCollection 2025 Sep.
4
An update on the effect of metals on stemness properties of mesenchymal stem cells.金属对间充质干细胞干性特性影响的最新进展。
J Mater Sci Mater Med. 2025 May 20;36(1):44. doi: 10.1007/s10856-025-06865-8.
5
Skeletal stem/progenitor cell-derived rather than osteoblast-derived IGF2 supports the development and homeostasis of skeletal system via STAT3.骨骼干细胞/祖细胞而非成骨细胞来源的胰岛素样生长因子2（IGF2）通过信号转导和转录激活因子3（STAT3）支持骨骼系统的发育和稳态。
Int J Biol Sci. 2025 Apr 28;21(7):3229-3246. doi: 10.7150/ijbs.112605. eCollection 2025.
6
Identification and function of periosteal skeletal stem cells in skeletal development, homeostasis, and disease.骨膜骨骼干细胞在骨骼发育、体内平衡及疾病中的鉴定与功能
J Orthop Translat. 2025 Mar 14;51:177-186. doi: 10.1016/j.jot.2025.01.010. eCollection 2025 Mar.
7
Challenges of engineering a functional growth plate .构建功能性生长板的挑战。
Front Bioeng Biotechnol. 2025 Mar 4;13:1550713. doi: 10.3389/fbioe.2025.1550713. eCollection 2025.
8
SARS-CoV-2 Impairs Osteoblast Differentiation Through Spike Glycoprotein and Cytokine Dysregulation.严重急性呼吸综合征冠状病毒2通过刺突糖蛋白和细胞因子失调损害成骨细胞分化。
Viruses. 2025 Jan 22;17(2):143. doi: 10.3390/v17020143.
9
Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration.利用内源性骨骼干细胞的多样性和潜力促进肌肉骨骼组织再生。
Stem Cells. 2025 Mar 10;43(3). doi: 10.1093/stmcls/sxaf006.
10
Jansen metaphyseal chondrodysplasia: analysis of craniofacial manifestations.詹森干骺端软骨发育不良：颅面部表现分析
JBMR Plus. 2024 Nov 26;9(2):ziae156. doi: 10.1093/jbmrpl/ziae156. eCollection 2025 Feb.
本文引用的文献
1
Identification and specification of the mouse skeletal stem cell.小鼠骨骼干细胞的鉴定与特性研究
Cell. 2015 Jan 15;160(1-2):285-98. doi: 10.1016/j.cell.2014.12.002.
2
Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.Gremlin 1可识别一种具有形成骨、软骨和网状基质潜能的骨骼干细胞。
Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042.
3
"Mesenchymal" stem cells.间充质干细胞。
Annu Rev Cell Dev Biol. 2014;30:677-704. doi: 10.1146/annurev-cellbio-100913-013132. Epub 2014 Aug 18.
4
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation.肥大的软骨细胞可在软骨内骨形成中成为成骨细胞和骨细胞。
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12097-102. doi: 10.1073/pnas.1302703111. Epub 2014 Aug 4.
5
Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow.表达瘦素受体的间充质基质细胞是成年骨髓形成骨骼的主要来源。
Cell Stem Cell. 2014 Aug 7;15(2):154-68. doi: 10.1016/j.stem.2014.06.008. Epub 2014 Jun 19.
6
Directed differentiation of human induced pluripotent stem cells toward bone and cartilage: in vitro versus in vivo assays.人诱导多能干细胞向骨和软骨的定向分化：体外与体内检测。
Stem Cells Transl Med. 2014 Jul;3(7):867-78. doi: 10.5966/sctm.2013-0154. Epub 2014 May 22.
7
Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model.临床路径：在非人类灵长类动物模型中对基于诱导多能干细胞的细胞疗法进行体内评估。
Cell Rep. 2014 May 22;7(4):1298-1309. doi: 10.1016/j.celrep.2014.04.019. Epub 2014 May 15.
8
Establishment of bone marrow and hematopoietic niches in vivo by reversion of chondrocyte differentiation of human bone marrow stromal cells.通过逆转人骨髓基质细胞的软骨细胞分化在体内建立骨髓和造血微环境。
Stem Cell Res. 2014 May;12(3):659-72. doi: 10.1016/j.scr.2014.01.006. Epub 2014 Feb 8.
9
Bone marrow stromal cell assays: in vitro and in vivo.骨髓基质细胞检测：体内和体外实验
Methods Mol Biol. 2014;1130:279-293. doi: 10.1007/978-1-62703-989-5_21.
10
Regulation of mesenchymal stem cell differentiation.间质干细胞分化的调控。
Adv Exp Med Biol. 2013;786:213-29. doi: 10.1007/978-94-007-6621-1_12.
Zotero 插件