Boothe Dawn Merton, Boothe Harry W
Clinical Pharmacology Laboratory, Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 1130 Wire Road, Auburn, AL 36849, USA.
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, 1220 Wire Road, Auburn, AL 36849, USA.
Vet Clin North Am Small Anim Pract. 2015 May;45(3):585-608. doi: 10.1016/j.cvsm.2015.01.006. Epub 2015 Mar 7.
Surgical site infections are among the complications that can be reduced with the timely implementation of appropriate antimicrobial therapy. A 3-D approach to judicious antimicrobial use focuses on the de-escalation of systemic antimicrobial therapy, design of dosing regimens, and decontamination of the surgeon, patient, and environment. De-escalation can be accomplished in part through proper antimicrobial prophylaxis. Dosing regimens should be designed to maximize efficacy and minimize resistance. Decontamination includes disinfection of inanimate surfaces and timely application of appropriate antiseptics at concentrations that maximize efficacy.
手术部位感染是可通过及时实施适当的抗菌治疗得以减少的并发症之一。明智使用抗菌药物的三维方法侧重于全身抗菌治疗的降阶梯、给药方案的设计以及对手术医生、患者和环境的去污处理。降阶梯可部分通过适当的抗菌预防来实现。给药方案的设计应旨在使疗效最大化并使耐药性最小化。去污处理包括对无生命表面进行消毒，以及及时应用浓度能使疗效最大化的适当防腐剂。
