Xu Jianping, Xiao Xinhua, Li Yuxiu, Zheng Jia, Li Wenhui, Zhang Qian, Wang Zhixin
Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, The Ministry of Health Key Laboratory of Endocrinology, Beijing, 100730, China.
Endocrine. 2015 Sep;50(1):93-8. doi: 10.1007/s12020-015-0566-1. Epub 2015 Mar 11.
We evaluated the effect of chewing on blood GLP-1 concentration by having volunteers to chew sugarless gum. Our intention was to explore the neural mechanisms regulating the secretion of glucagon-like peptide-1(GLP-1). After fasting for 12 h, 12 healthy male, non-obese volunteers (18 < BMI < 30), were asked to chew sugarless gum at a frequency of 80 times every 2 min for a total of 30 min. Blood samples were collected before the start of chewing and 5, 10, 15, 20, 25, and 30 min after the start of chewing. Satiety and hunger were evaluated on a scale from 0 to 100 at each time point. Compared with the control group, the test group's satiety was increased at 15, 25, and 30 min (p = 0.043, p = 0.014 and p = 0.018, respectively) after they began chewing sugarless gum 80 times every 2 min. The blood GLP-1 level of the test group at 30 min was 49.6 ± 20.3 pmol/l, significantly higher than that of the control group (38.9 ± 20.9 pmol/l; p = 0.031). There was no significant difference in the test group's GLP-1 concentration at each time point. In the control group, compared to baseline, the GLP-1 concentrations at 15, 25, and 30 min were significantly decreased (p = 0.042, p = 0.0214 and p = 0.012, respectively). No significant differences in the blood concentration of glucose, insulin and GIP or hunger were observed between groups. Our study suggests that fasting sugarless gum chewing can increase satiety and reduce the decrease in GLP-1 concentration.
我们通过让志愿者咀嚼无糖口香糖来评估咀嚼对血液中胰高血糖素样肽-1（GLP-1）浓度的影响。我们的目的是探索调节胰高血糖素样肽-1（GLP-1）分泌的神经机制。在禁食12小时后，12名健康的非肥胖男性志愿者（体重指数18＜BMI＜30）被要求以每2分钟80次的频率咀嚼无糖口香糖，共咀嚼30分钟。在咀嚼开始前以及开始咀嚼后5、10、15、20、25和30分钟采集血样。在每个时间点，采用0至100分的量表对饱腹感和饥饿感进行评估。与对照组相比，试验组在开始每2分钟咀嚼80次无糖口香糖后的15、25和30分钟时饱腹感增加（分别为p = 0.043、p = 0.014和p = 0.018）。试验组在30分钟时的血液GLP-1水平为49.6±20.3 pmol/l，显著高于对照组（38.9±20.9 pmol/l；p = 0.031）。试验组在各个时间点的GLP-1浓度无显著差异。在对照组中，与基线相比，15、25和30分钟时的GLP-1浓度显著降低（分别为p = 0.042、p = 0.0214和p = 0.012）。两组之间在血糖、胰岛素和GIP的血液浓度或饥饿感方面未观察到显著差异。我们的研究表明，禁食时咀嚼无糖口香糖可增加饱腹感并减少GLP-1浓度的下降。
