Greenway Frank, O'Neil Carol E, Stewart Laura, Rood Jennifer, Keenan Michael, Martin Roy
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.
J Med Food. 2007 Dec;10(4):720-4. doi: 10.1089/jmf.2007.405.
Fermentable dietary fiber has been shown to cause fat loss and to increase peptide-YY (PYY) and glucagon-like peptide 1 (GLP-1) levels in rodents. In single meal tests, humans have an increase in PYY and GLP-1 to dietary fiber, but the response of these hormones to longer-term treatment is not known. Viscofiber (Cevena Bioproducts Inc., Edmonton, AB, Canada) is a high-viscosity fermentable dietary fiber made by a proprietary process from oats and barley. Seven healthy overweight and obese subjects were treated with a calorie-restricted diet, a lifestyle change program, and 4 g of Viscofiber/day for 16 weeks. Hunger, satiety, PYY, and GLP-1 were measured before and 1 hour after a standard meal test before and at week 14 of the study. Hunger and satiety were measured by Visual Analog Scales. PYY and GLP-1 were measured by radioimmunoassay and enzyme-linked immunosorbent assay, respectively. Weight was reduced 3.07 +/- 3.13 kg (P < .05) over the 16 weeks. Fasting PYY increased 8.67 +/- 6.62 pg/mL (P < .05) and fasting GLP-1 increased 2.67 +/- 0.84 pmol/L (P < .01) at 14 weeks compared to baseline. Satiety increased 1.78 +/- 1.43 cm (P < .01) at the 1-hour post-meal time point on week 14 compared to the study baseline. We conclude that 14 weeks of treatment with Viscofiber at 4 g/day along with a lifestyle change program and diet causes weight loss and increases fasting PYY, fasting GLP-1, and satiety at 1 hour following a standard meal, which extends the single meal test observations in humans.
已证实，可发酵膳食纤维能使啮齿动物减脂，并提高其肽YY（PYY）和胰高血糖素样肽1（GLP-1）水平。在单次进餐测试中，人体摄入膳食纤维后PYY和GLP-1水平会升高，但这些激素对长期治疗的反应尚不清楚。Viscofiber（加拿大阿尔伯塔省埃德蒙顿市的Cevena生物制品公司）是一种高粘度可发酵膳食纤维，通过专有工艺由燕麦和大麦制成。7名健康的超重和肥胖受试者接受了为期16周的热量限制饮食、生活方式改变计划，以及每天4克Viscofiber的治疗。在研究的第14周和之前，于标准进餐测试前及餐后1小时测量饥饿感、饱腹感、PYY和GLP-1。通过视觉模拟量表测量饥饿感和饱腹感。分别采用放射免疫分析法和酶联免疫吸附测定法测量PYY和GLP-1。在16周内体重减轻了3.07±3.13千克（P<.05）。与基线相比，第14周时空腹PYY增加了8.67±6.62皮克/毫升（P<.05），空腹GLP-1增加了2.67±0.84皮摩尔/升（P<.01）。与研究基线相比，第14周餐后1小时时饱腹感增加了1.78±1.43厘米（P<.01）。我们得出结论，每天4克Viscofiber治疗14周，同时配合生活方式改变计划和饮食，可导致体重减轻，并提高标准餐后1小时的空腹PYY、空腹GLP-1和饱腹感，这扩展了人体单次进餐测试的观察结果。
