高密度脂蛋白在血管生成调控中的作用。
The role of high-density lipoproteins in the regulation of angiogenesis.
机构信息
The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, New South Wales 2042, Australia Sydney Medical School, University of Sydney, Sydney, Australia.
The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, New South Wales 2042, Australia Sydney Medical School, University of Sydney, Sydney, Australia Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.
出版信息
Cardiovasc Res. 2015 May 1;106(2):184-93. doi: 10.1093/cvr/cvv104. Epub 2015 Mar 10.
Angiogenesis is important for postnatal physiological processes including tissue neovascularization in response to an ischaemic injury. Conversely, uncontrolled inflammatory-driven angiogenesis can accelerate atherosclerotic plaque and tumour growth. Angiogenesis-associated diseases are highly prevalent globally, with cardiovascular-related disorders and cancer being the leading causes of mortality worldwide. A vast amount of research has been conducted on the vasculoprotective effects of high-density lipoproteins (HDLs) and while current HDL-raising therapies to date have not yielded the desired benefits clinically, its role in angiogenesis is yet to be fully elucidated. Epidemiological studies report positive correlations between elevated HDL levels and improved prognosis in both ischaemia- and inflammatory-driven pathologies, in which angiogenesis plays a key role. This review focuses on current evidence from epidemiological and prospective studies, coupled with animal models and mechanistic studies that highlight the ability of HDL to conditionally regulate angiogenesis.
血管生成对于产后生理过程很重要，包括对缺血损伤的组织新生血管生成的反应。相反，不受控制的炎症驱动的血管生成会加速动脉粥样硬化斑块和肿瘤的生长。与血管生成相关的疾病在全球非常普遍，心血管相关疾病和癌症是全球死亡的主要原因。大量研究集中在高密度脂蛋白（HDL）的血管保护作用上，尽管迄今为止针对 HDL 升高的治疗方法在临床上没有产生预期的效果，但它在血管生成中的作用尚未完全阐明。流行病学研究报告称，在缺血和炎症驱动的病理中，升高的 HDL 水平与改善预后之间存在正相关，而血管生成在其中起着关键作用。本综述重点介绍了来自流行病学和前瞻性研究的最新证据，以及动物模型和机制研究的证据，这些证据突出了 HDL 调节血管生成的条件能力。
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