通过体外微流控平台模拟转移级联反应。
Modelling the metastatic cascade by in vitro microfluidic platforms.
作者信息
Samatov Timur R, Shkurnikov Maxim U, Tonevitskaya Svetlana A, Tonevitsky Alexander G
机构信息
SRC Bioclinicum, Ugreshskaya str 2/85, 115088 Moscow, Russia; Moscow State University of Mechanical Engineering, Bolshaya Semenovskaya str 38, 107023 Moscow, Russia.
Hertsen Federal Medical Research Centre of the Ministry of Health of the Russian Federation, Koroleva str 4, 249036 Obninsk, 5 Russia.
出版信息
Prog Histochem Cytochem. 2015 Jan;49(4):21-9. doi: 10.1016/j.proghi.2015.01.001. Epub 2015 Feb 7.
The metastatic cascade comprises the following steps in sequential manner: the future metastatic cell has to leave the primary tumor mass, degrade the surrounding extracellular matrix, extravasate and circulate within in the bloodstream. Thereafter it has to attach to the endothelium of a target organ, intravasate into the connective tissue and has to proliferate to form a clinically detectable metastasis. We overview the in vitro microfluidic platforms modelling the metastatic cascade and the evolution towards systems capable of recapitulating all the steps by a single comprehensive model.
转移级联反应按顺序包括以下步骤
未来的转移细胞必须离开原发肿瘤块，降解周围的细胞外基质，渗出并在血液中循环。此后，它必须附着于靶器官的内皮，渗入结缔组织并增殖以形成临床上可检测到的转移灶。我们概述了模拟转移级联反应的体外微流控平台，以及向能够通过单一综合模型概括所有步骤的系统的发展。
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