• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[具体基因名称]和[具体基因名称]基因的表达对乳腺癌细胞转移潜能的影响。 （你提供的原文中基因名称部分缺失，我根据格式推测补充了这部分内容，你可根据实际情况修改完善）

Effect of the Expression of and Genes on the Metastatic Potential of Breast Cancer Cells.

作者信息

Nikulin Sergey, Zakharova Galina, Poloznikov Andrey, Raigorodskaya Maria, Wicklein Daniel, Schumacher Udo, Nersisyan Stepan, Bergquist Jonas, Bakalkin Georgy, Astakhova Lidiia, Tonevitsky Alexander

机构信息

Faculty of Biology and Biotechnologies, National Research University Higher School of Economics, Moscow, Russia.

Scientific Research Centre Bioclinicum, Moscow, Russia.

出版信息

Front Genet. 2021 Jun 2;12:662843. doi: 10.3389/fgene.2021.662843. eCollection 2021.

DOI:10.3389/fgene.2021.662843
PMID:34149804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8206645/
Abstract

Breast cancer (BC) is the leading cause of death from malignant neoplasms among women worldwide, and metastatic BC presents the biggest problems for treatment. Previously, it was shown that lower expression of and genes is associated with a higher risk of the formation of distant metastases in BC. In this work, we studied the change in phenotypical traits, as well as in the transcriptomic and proteomic profiles of BC cells as a result of the stable knockdown of and genes. The knockdown of and genes was found to lead to a strong increase in the expression of the matrix metalloproteinase (MMP) . These results were in good agreement with the correlation analysis of gene expression in tumor samples from patients and were additionally confirmed by zymography. The knockdown of and genes was also discovered to change the expression of a group of genes involved in the formation of intercellular contacts. In particular, the expression of the gene was markedly reduced, which also complies with the correlation analysis. The spheroid formation assay showed that intercellular adhesion decreased as a result of the knockdown of the and genes. Thus, the obtained data indicate that malignant breast tumors with reduced expression of the and genes can metastasize with a higher probability due to a more efficient invasion of tumor cells.

摘要

乳腺癌（BC）是全球女性恶性肿瘤死亡的主要原因，而转移性乳腺癌是治疗中面临的最大问题。此前研究表明，[具体基因1]和[具体基因2]基因的低表达与乳腺癌远处转移形成的高风险相关。在本研究中，我们研究了[具体基因1]和[具体基因2]基因稳定敲低后乳腺癌细胞表型特征、转录组和蛋白质组图谱的变化。发现[具体基因1]和[具体基因2]基因的敲低导致基质金属蛋白酶（MMP）[具体MMP名称]的表达大幅增加。这些结果与患者肿瘤样本中基因表达的相关性分析结果高度一致，并通过酶谱法得到进一步证实。还发现[具体基因1]和[具体基因2]基因的敲低改变了一组参与细胞间接触形成的基因的表达。特别是，[具体基因3]基因的表达明显降低，这也与相关性分析结果相符。球体形成试验表明，[具体基因1]和[具体基因2]基因敲低后细胞间粘附减少。因此，获得的数据表明，[具体基因1]和[具体基因2]基因表达降低的恶性乳腺肿瘤由于肿瘤细胞更有效的侵袭而更有可能发生转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/1e6ead68aa9f/fgene-12-662843-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/d7722a46a4b8/fgene-12-662843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/09e16b4b6d3d/fgene-12-662843-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/05de2c598261/fgene-12-662843-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/043171f9328d/fgene-12-662843-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/625689b7516e/fgene-12-662843-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/8a0295d5dfad/fgene-12-662843-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/49a7f472590c/fgene-12-662843-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/7a9de6bb2742/fgene-12-662843-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/e62bacdb4cc8/fgene-12-662843-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/1e6ead68aa9f/fgene-12-662843-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/d7722a46a4b8/fgene-12-662843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/09e16b4b6d3d/fgene-12-662843-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/05de2c598261/fgene-12-662843-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/043171f9328d/fgene-12-662843-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/625689b7516e/fgene-12-662843-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/8a0295d5dfad/fgene-12-662843-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/49a7f472590c/fgene-12-662843-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/7a9de6bb2742/fgene-12-662843-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/e62bacdb4cc8/fgene-12-662843-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f853/8206645/1e6ead68aa9f/fgene-12-662843-g010.jpg

相似文献

1
Effect of the Expression of and Genes on the Metastatic Potential of Breast Cancer Cells.[具体基因名称]和[具体基因名称]基因的表达对乳腺癌细胞转移潜能的影响。 （你提供的原文中基因名称部分缺失，我根据格式推测补充了这部分内容，你可根据实际情况修改完善）
Front Genet. 2021 Jun 2;12:662843. doi: 10.3389/fgene.2021.662843. eCollection 2021.
2
and genes modulate sensitivity of breast cancer cells to ferroptosis.并且基因调节乳腺癌细胞对铁死亡的敏感性。
Front Mol Biosci. 2023 Jan 13;10:1075704. doi: 10.3389/fmolb.2023.1075704. eCollection 2023.
3
IGFBP6 regulates extracellular vesicles formation via cholesterol abundance in MDA-MB-231 cells.胰岛素样生长因子结合蛋白6通过MDA-MB-231细胞中胆固醇的丰度调节细胞外囊泡的形成。
Biochimie. 2024 Dec;227(Pt A):77-85. doi: 10.1016/j.biochi.2024.06.011. Epub 2024 Jun 26.
4
Transcriptome Guided Drug Combination Suppresses Proliferation of Breast Cancer Cells.转录组引导的药物联合疗法抑制乳腺癌细胞增殖。
Bull Exp Biol Med. 2019 Mar;166(5):656-660. doi: 10.1007/s10517-019-04412-4. Epub 2019 Mar 22.
5
In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing.用于研究IGFBP6基因在乳腺癌转移中作用的体外模型
Bull Exp Biol Med. 2018 Mar;164(5):688-692. doi: 10.1007/s10517-018-4060-7. Epub 2018 Mar 27.
6
Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes.胰岛素样生长因子结合蛋白6（IGFBP6）蛋白在上皮-间质转化基因调控中的作用
Bull Exp Biol Med. 2018 Mar;164(5):650-654. doi: 10.1007/s10517-018-4051-8. Epub 2018 Mar 26.
7
Changes in the Metastatic Properties of MDA-MB-231 Cells after IGFBP6 Gene Knockdown Is Associated with Increased Expression of miRNA Genes Controlling INSR, IGF1R, and CCND1 Genes.IGFBP6基因敲低后MDA-MB-231细胞转移特性的变化与调控INSR、IGF1R和CCND1基因的miRNA基因表达增加有关。
Bull Exp Biol Med. 2019 Mar;166(5):641-645. doi: 10.1007/s10517-019-04409-z. Epub 2019 Mar 22.
8
The Crosstalk between GPR81/IGFBP6 Promotes Breast Cancer Progression by Modulating Lactate Metabolism and Oxidative Stress.GPR81/IGFBP6之间的相互作用通过调节乳酸代谢和氧化应激促进乳腺癌进展。
Antioxidants (Basel). 2022 Jan 29;11(2):275. doi: 10.3390/antiox11020275.
9
Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors.Elovl5 下调通过脂滴积累介导的 TGF-β 受体诱导促进乳腺癌转移。
Cell Death Dis. 2022 Sep 2;13(9):758. doi: 10.1038/s41419-022-05209-6.
10
Effect of IGFBP6 Knockdown on Proteins Regulating Exosome Synthesis and Secretion in MDA-MB-231 Cell Line.IGFBP6 敲低对 MDA-MB-231 细胞系中调节外泌体合成和分泌的蛋白质的影响。
Bull Exp Biol Med. 2023 May;175(1):157-161. doi: 10.1007/s10517-023-05828-9. Epub 2023 Jun 19.

引用本文的文献

1
Very long-chain fatty acids accumulate in breast cancer tissue and serum.极长链脂肪酸在乳腺癌组织和血清中蓄积。
Cancer Cell Int. 2025 Aug 4;25(1):296. doi: 10.1186/s12935-025-03928-2.
2
IGFBP6 Modulates Proteostasis by Activating ATF4 Targets and Reducing ER Retrotranslocon Expression.胰岛素样生长因子结合蛋白6通过激活ATF4靶点和降低内质网逆向转运体表达来调节蛋白质稳态。
Dokl Biochem Biophys. 2024 Dec;519(1):486-492. doi: 10.1134/S1607672924600714. Epub 2024 Oct 31.
3
Identification of 10 differentially expressed genes involved in the tumorigenesis of cervical cancer next-generation sequencing.

本文引用的文献

1
Algorithmic Annotation of Functional Roles for Components of 3,044 Human Molecular Pathways.3044条人类分子通路组成成分功能角色的算法注释
Front Genet. 2021 Feb 9;12:617059. doi: 10.3389/fgene.2021.617059. eCollection 2021.
2
Molecular Pathway Activation Markers Are Associated with Efficacy of Trastuzumab Therapy in Metastatic HER2-Positive Breast Cancer Better than Individual Gene Expression Levels.分子通路激活标志物与曲妥珠单抗治疗转移性 HER2 阳性乳腺癌的疗效相关，优于单个基因表达水平。
Biochemistry (Mosc). 2020 Jul;85(7):758-772. doi: 10.1134/S0006297920070044.
3
Nuclear localization and actions of the insulin-like growth factor 1 (IGF-1) system components: Transcriptional regulation and DNA damage response.
基于下一代测序的宫颈癌发生中 10 个差异表达基因的鉴定。
PeerJ. 2024 Oct 2;12:e18157. doi: 10.7717/peerj.18157. eCollection 2024.
4
Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer.赖氨酸酰化（Kla）可能成为乳腺癌的一个新的治疗靶点。
BMC Med Genomics. 2023 Nov 10;16(1):283. doi: 10.1186/s12920-023-01726-1.
5
Coherent pathway enrichment estimation by modeling inter-pathway dependencies using regularized regression.使用正则化回归建模通路间的依赖关系进行连贯通路富集估计。
Bioinformatics. 2023 Aug 1;39(8). doi: 10.1093/bioinformatics/btad522.
6
Emerging roles of polyunsaturated fatty acid synthesis pathway in colorectal cancer.多不饱和脂肪酸合成途径在结直肠癌中的新作用。
Anim Cells Syst (Seoul). 2023 Mar 20;27(1):61-71. doi: 10.1080/19768354.2023.2189933. eCollection 2023.
7
and genes modulate sensitivity of breast cancer cells to ferroptosis.并且基因调节乳腺癌细胞对铁死亡的敏感性。
Front Mol Biosci. 2023 Jan 13;10:1075704. doi: 10.3389/fmolb.2023.1075704. eCollection 2023.
8
Hairpin sequence and structure is associated with features of isomiR biogenesis.发夹序列和结构与 isomiR 生物发生的特征相关。
RNA Biol. 2021 Oct 15;18(sup1):430-438. doi: 10.1080/15476286.2021.1952759. Epub 2021 Jul 21.
胰岛素样生长因子 1（IGF-1）系统成分的核定位和作用：转录调控和 DNA 损伤反应。
Mutat Res Rev Mutat Res. 2020 Apr-Jun;784:108307. doi: 10.1016/j.mrrev.2020.108307. Epub 2020 Feb 27.
4
Knockdown of the α5 laminin chain affects differentiation of colorectal cancer cells and their sensitivity to chemotherapy.敲低α5 层粘连蛋白链会影响结直肠癌细胞的分化及其对化疗的敏感性。
Biochimie. 2020 Jul;174:107-116. doi: 10.1016/j.biochi.2020.04.016. Epub 2020 Apr 22.
5
Decreased expression of IGFBP6 correlates with poor survival in colorectal cancer patients.IGFBP6 表达降低与结直肠癌患者预后不良相关。
Pathol Res Pract. 2020 May;216(5):152909. doi: 10.1016/j.prp.2020.152909. Epub 2020 Feb 29.
6
Cell adhesion in cancer: Beyond the migration of single cells.癌细胞黏附：超越单细胞迁移。
J Biol Chem. 2020 Feb 21;295(8):2495-2505. doi: 10.1074/jbc.REV119.007759. Epub 2020 Jan 14.
7
CD44 Regulates Formation of Spheroids and Controls Organ-Specific Metastatic Colonization in Epithelial Ovarian Carcinoma.CD44 调节球体的形成，并控制上皮性卵巢癌的器官特异性转移定植。
Mol Cancer Res. 2019 Sep;17(9):1801-1814. doi: 10.1158/1541-7786.MCR-18-1205. Epub 2019 May 30.
8
Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer.整合素连接激酶（ILK）在肿瘤发生中的意义及其作为人类癌症生物标志物和治疗靶点的潜在意义。
Am J Cancer Res. 2019 Jan 1;9(1):186-197. eCollection 2019.
9
Retroelement-Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution.逆转录元件相关转录因子结合模式指向人类进化中快速发展的分子途径。
Cells. 2019 Feb 6;8(2):130. doi: 10.3390/cells8020130.
10
MMP-1 is overexpressed in triple-negative breast cancer tissues and the knockdown of MMP-1 expression inhibits tumor cell malignant behaviors .基质金属蛋白酶-1（MMP-1）在三阴性乳腺癌组织中过表达，敲低MMP-1表达可抑制肿瘤细胞的恶性行为。
Oncol Lett. 2019 Feb;17(2):1732-1740. doi: 10.3892/ol.2018.9779. Epub 2018 Nov 30.