Gabutti Giovanni, Rota Maria Cristina, De Donno Antonella, Guido Marcello, Bella Antonino, Idolo Adele, Lupi Silvia, Brignole Giordana
1Scuola di specializzazione in igiene e medicina preventiva, Università di Ferrara, Ferrara.
Epidemiol Prev. 2014 Nov-Dec;38(6 Suppl 2):57-61.
Eight Italian Regions have begun offering vaccination against varicella to children aged 13-15 months, with a second dose at 5-6 years of age. A serosurvey was conducted to evaluate the impact of extensive vaccination in these "pilot" Regions.
Samples were collected in compliance with current legislation and after the approval of the Ethics Committee. The qualitative and quantitative determination of antibodies (IgG) against varicella was performed using an ELISA assay with high sensitivity and specificity.
1,470 samples were analyzed. After the decrease of seropositivity associated with the decay of passively acquired antibody titer, there was a progressive increase of seroprevalence in the other age groups. The comparison with what was recorded in two studies conducted with similar assays in the periods 1996/97 and 2003/04, showed a significant increase in seroprevalence following extensive immunization, particularly in the age classes 1 year, 2-4 years and 5-9 years. The proportion of seropositivity in the age classes 1 year and 2-4 years has more than doubled.
Seroepidemiological studies are a useful tool to evaluate the distribution of susceptible individuals in the population. This study highlighted the impact of extensive vaccination against varicella in eight "pilot" Regions.
意大利的八个大区已开始为13至15个月大的儿童接种水痘疫苗，并在5至6岁时接种第二剂。开展了一项血清学调查，以评估在这些“试点”大区广泛接种疫苗的影响。
样本采集符合现行法规并经伦理委员会批准。采用具有高灵敏度和特异性的ELISA检测法对水痘抗体（IgG）进行定性和定量测定。
分析了1470份样本。随着被动获得的抗体滴度下降导致血清阳性率降低，其他年龄组的血清流行率逐渐上升。与1996/97年和2003/04年期间采用类似检测法进行的两项研究记录的情况相比，广泛免疫后血清流行率显著上升，尤其是在1岁、2至4岁和5至9岁年龄组。1岁和2至4岁年龄组的血清阳性率比例增加了一倍多。
血清流行病学研究是评估人群中易感个体分布的有用工具。本研究突出了在八个“试点”大区广泛接种水痘疫苗的影响。
