N-乙酰半胱氨酸治疗静脉注射胺碘酮所致肝损伤。
N-acetylcysteine treats intravenous amiodarone induced liver injury.
作者信息
Mudalel Matthew L, Dave Kartikeya P, Hummel James P, Solga Steven F
机构信息
Matthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
出版信息
World J Gastroenterol. 2015 Mar 7;21(9):2816-9. doi: 10.3748/wjg.v21.i9.2816.
Abstract
We report a case of intravenous (IV) amiodarone drug induced liver injury (DILI). The patient received IV N-acetylcysteine (NAC) which resulted in a rapid improvement in liver enzymes. While the specific mechanisms for the pathogenesis of IV amiodarone DILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality. Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.
摘要
我们报告了一例静脉注射胺碘酮所致药物性肝损伤（DILI）的病例。该患者接受了静脉注射N-乙酰半胱氨酸（NAC）治疗，结果肝酶迅速改善。虽然静脉注射胺碘酮所致DILI的发病机制及静脉注射NAC的治疗作用均不明，但该病例强烈提示至少存在一些共性。由于静脉注射胺碘酮用于重症监护病房中严重心律失常的治疗，在大多数病例中，某种程度的缺血性肝炎可能是一个辅助因素。
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