三例同时性 HER2 阳性乳腺癌伴甲状腺癌
Three Metachronous Cases of HER2-Positive Breast Cancer Accompanied with Thyroid Cancer.
机构信息
The first Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
出版信息
Breast Care (Basel). 2014 Oct;9(5):360-3. doi: 10.1159/000358861.
BACKGROUND
Breast carcinoma (BC) and papillary thyroid carcinoma (PTC) occur predominantly in women. Many studies have shown that PTC is common among women with BC. Collision metastases in lymph nodes do occur but are not common.
CASE REPORT
Here we report 3 metachronous cases of BC with PTC. PTC developed after BC in each case. Histology and immunohistochemistry revealed that HER2 status was positive in each BC, and in 1, concurrent metastases of BC and PTC were shown in a lymph node of the left cervical region.
CONCLUSION
From our results, we speculate that women with HER2-positive breast cancer may be at a higher risk for thyroid cancer than other cancers. Finding 2 distinct types of cancer metastasized to 1 lymph node in a patient may, therefore, warrant a high index of suspicion and the use of immunohistochemical stains to differentiate the types of collision tumors.
背景
乳腺癌（BC）和甲状腺乳头状癌（PTC）主要发生在女性中。许多研究表明，PTC 在患有 BC 的女性中很常见。淋巴结中的碰撞转移确实会发生，但并不常见。
病例报告
在这里，我们报告了 3 例 BC 伴 PTC 的同时性病例。在每种情况下，PTC 均在 BC 之后发生。组织学和免疫组织化学显示，每个 BC 的 HER2 状态均为阳性，并且在 1 例中，左颈部区域的 1 个淋巴结中显示了 BC 和 PTC 的并发转移。
结论
根据我们的结果，我们推测 HER2 阳性乳腺癌的女性患甲状腺癌的风险可能高于其他癌症。在患者的 1 个淋巴结中发现 2 种不同类型的癌症转移，因此需要高度怀疑并使用免疫组织化学染色来区分碰撞肿瘤的类型。
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