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乳腺癌转移至甲状腺：一项回顾性分析。

Breast cancer metastasis to thyroid: a retrospective analysis.

作者信息

Zhou Lingyan, Chen Liyu, Xu Dong, Shao Qi, Guo Zhenying, Ge Minghua

机构信息

Department of Ultrasound, Zhe Jiang Cancer Hospital affiliated to Zhejiang Chinese Medical University, Guangji road 38, GongShuQu, Hangzhou 310022, Zhejiang, China.

Department of Pathology, Zhe Jiang Cancer Hospital, Hangzhou, Zhe jiang province, China.

出版信息

Afr Health Sci. 2017 Dec;17(4):1035-1043. doi: 10.4314/ahs.v17i4.11.

DOI:10.4314/ahs.v17i4.11
PMID:29937874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5870294/
Abstract

BACKGROUND

Breast cancers metastasizing to thyroid gland are relatively uncommon in clinical practice.

OBJECTIVE

Retrospective analysis of data from breast cancer patients with thyroid metastasis (TM).

METHODS

The US suspected, fine-needle aspiration cytology (FNAC) confirmed TM in breast cancer patients, treated between 2005 and 2015 at our hospital, was retrospectively analyzed. The data were re-evaluated by the pathologist and radiologist who were blinded to the patients' data.

RESULTS

FNAC and immunohistochemistry confirmed the ultrasonography (US) suspected TM in eight breast cancer patients. Clinically both unilateral and bilateral TM was seen, which were symptomless and metachronously (6-121 months) metastasized. Six of eight cases exhibited recurrence/distant metastasis and were treated with chemotherapy/thyroidectomy of which two cases passed away. The remaining two patients had no recurrences/distant metastases and were treated with partial/total thyroidectomy. Post-chemotherapy US showed more homogenous thyroid parenchyma with gathering of calcification that reduced in size, revealing the sensitiveness of TM to chemotherapy.

CONCLUSION

US was useful in screening TM in breast cancer patients. Both partial and total thyroidectomy was effective in disease free survival of isolated TM cases, with controlled primary condition. TM responded well to chemotherapy in most of the recurrent breast cancer cases with or without distant metastasis.

摘要

背景

在临床实践中，乳腺癌转移至甲状腺相对少见。

目的

对乳腺癌甲状腺转移（TM）患者的数据进行回顾性分析。

方法

回顾性分析2005年至2015年在我院接受治疗的乳腺癌患者中，经美国超声检查怀疑、细针穿刺细胞学检查（FNAC）确诊为TM的患者数据。数据由对患者数据不知情的病理学家和放射科医生重新评估。

结果

FNAC和免疫组化证实8例乳腺癌患者经超声检查（US）怀疑的TM。临床上可见单侧和双侧TM，均无症状且为异时性转移（6 - 121个月）。8例中有6例出现复发/远处转移，接受了化疗/甲状腺切除术，其中2例死亡。其余2例患者无复发/远处转移，接受了部分/全甲状腺切除术。化疗后超声显示甲状腺实质更均匀，钙化聚集且大小减小，显示TM对化疗敏感。

结论

超声有助于筛查乳腺癌患者的TM。部分和全甲状腺切除术对孤立TM病例在控制原发病情的情况下实现无病生存有效。在大多数有或无远处转移的复发性乳腺癌病例中，TM对化疗反应良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbd/5870294/644b66233cde/AFHS1704-1035Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbd/5870294/6f145a833f93/AFHS1704-1035Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbd/5870294/cf4af28e2ad6/AFHS1704-1035Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbd/5870294/644b66233cde/AFHS1704-1035Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbd/5870294/6f145a833f93/AFHS1704-1035Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbd/5870294/cf4af28e2ad6/AFHS1704-1035Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbd/5870294/644b66233cde/AFHS1704-1035Fig3.jpg

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Synchronous diagnosis of metastatic cancer to the thyroid is associated with poor prognosis.同步诊断甲状腺转移癌与不良预后相关。
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Thyroid metastasis from breast carcinoma accompanied by papillary thyroid carcinoma.乳腺癌伴甲状腺乳头状癌的甲状腺转移
乳腺癌与甲状腺肿瘤：一项双向双样本孟德尔随机化研究。
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Thyroid Metastases from Breast Cancer Case Report and Literature Review.乳腺癌甲状腺转移：病例报告与文献综述
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