Nie Sheng, Li Keqin, Huang Yi, Hu Qinle, Gao Xiang, Jie Sun
From the First Hospital, Ning Bo, Zhejiang Province, China.
J Craniofac Surg. 2015 Mar;26(2):e155-8. doi: 10.1097/SCS.0000000000001385.
Cancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon known as the Warburg effect. Whether the deregulation of microRNAs contributes to the Warburg effect remains largely unknown. Here, we show that miR-495 expression is decreased and thus induces a metabolic shift in glioma cells. miR-495 performs this function by increasing the expression of Glut1, leading to the increase of glucose uptake and lactate production. The altered metabolism induced by miR-495 results in the rapid growth of cancer cells. These results identify miR-495 as a molecular switch involved in the orchestration of the Warburg effect in glioma cells via targeting the expression of Glut1.
癌细胞代谢通常以从氧化生物能学途径向糖酵解生物能学途径的转变为特征，这一现象被称为瓦伯格效应。微小RNA的失调是否导致瓦伯格效应在很大程度上仍然未知。在这里，我们表明miR-495的表达降低，从而在胶质瘤细胞中诱导代谢转变。miR-495通过增加Glut1的表达来发挥这一功能，导致葡萄糖摄取和乳酸生成增加。miR-495诱导的代谢改变导致癌细胞快速生长。这些结果确定miR-495是通过靶向Glut1的表达参与胶质瘤细胞中瓦伯格效应调控的分子开关。
