Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
Heilongjiang Academy of Medical Sciences, Harbin, 150086, China.
Signal Transduct Target Ther. 2020 Jun 19;5(1):102. doi: 10.1038/s41392-020-0194-y.
Immunotherapy, designed to exploit the functions of the host immune system against tumors, has shown considerable potential against several malignancies. However, the utility of immunotherapy is heavily limited due to the low response rate and various side effects in the clinical setting. Immune escape of tumor cells may be a critical reason for such low response rates. Noncoding RNAs (ncRNAs) have been identified as key regulatory factors in tumors and the immune system. Consequently, ncRNAs show promise as targets to improve the efficacy of immunotherapy in tumors. However, the relationship between ncRNAs and tumor immune escape (TIE) has not yet been comprehensively summarized. In this review, we provide a detailed account of the current knowledge on ncRNAs associated with TIE and their potential roles in tumor growth and survival mechanisms. This review bridges the gap between ncRNAs and TIE and broadens our understanding of their relationship, providing new insights and strategies to improve immunotherapy response rates by specifically targeting the ncRNAs involved in TIE.
免疫疗法旨在利用宿主免疫系统对抗肿瘤，已显示出对多种恶性肿瘤的巨大潜力。然而，由于临床疗效低和各种副作用，免疫疗法的应用受到严重限制。肿瘤细胞的免疫逃逸可能是这种低反应率的一个关键原因。非编码 RNA（ncRNA）已被确定为肿瘤和免疫系统中的关键调节因子。因此，ncRNA 有望成为提高肿瘤免疫治疗疗效的靶点。然而，ncRNA 与肿瘤免疫逃逸（TIE）之间的关系尚未得到全面总结。在这篇综述中，我们详细介绍了与 TIE 相关的 ncRNA 的最新知识及其在肿瘤生长和存活机制中的潜在作用。本综述弥合了 ncRNA 和 TIE 之间的差距，增进了我们对它们之间关系的理解，为通过特异性靶向参与 TIE 的 ncRNA 来提高免疫治疗反应率提供了新的见解和策略。
