Zhao Su-Feng, Wang Yu-Xin, Yang Xu-Dong, Tang En-Yi
From the Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Medical School, Nanjing University, Nanjing, People's Republic of China.
J Craniofac Surg. 2015 Mar;26(2):e160-2. doi: 10.1097/SCS.0000000000001387.
Gorham disease, or massive osteolysis, is a rare condition of unknown etiology. The disease is characterized by spontaneous progressive osteolysis of 1 or more skeletal bones. The mandible is the most commonly involved bone in the maxillofacial region. This article reports a case of Gorham disease with mandibular involvement in a 46-year-old male patient with a 7-year follow-up. In this case, we performed lower right mandibular osteotomy and reconstruction with a phased titanium plate. Postoperative follow-up showed continued mandibular bone loss that was progressing to the contralateral mandible. Massive osteolysis of the mandible is a rare clinical condition that must be differentiated from mandibularosteomyelitis, benign and malignant tumors, as well as hyperparathyroidism. Improved differential diagnoses and disease follow-up are required to effectively manage massive osteolysis.
戈谢病，或称大块骨溶解症，是一种病因不明的罕见病症。该疾病的特征是一个或多个骨骼发生自发性进行性骨溶解。下颌骨是颌面区域最常受累的骨骼。本文报告了一例46岁男性患者患戈谢病累及下颌骨并进行了7年随访的病例。在该病例中，我们进行了右下下颌骨截骨术并用分期钛板进行重建。术后随访显示下颌骨持续骨质流失，并向对侧下颌骨发展。下颌骨大块骨溶解是一种罕见的临床病症，必须与下颌骨骨髓炎、良性和恶性肿瘤以及甲状旁腺功能亢进相鉴别。需要改进鉴别诊断和疾病随访以有效管理大块骨溶解症。
