Paley M D, Lloyd C J, Penfold C N
Department of Oral and Maxillofacial Surgery, Glan Clwyd Hospital, Bodelwyddan, Rhyl, North Wales LL18 5UJ, UK.
Br J Oral Maxillofac Surg. 2005 Apr;43(2):166-8. doi: 10.1016/j.bjoms.2004.09.008.
Massive osteolysis (Gorham-Stout syndrome) is a rare condition of unknown aetiology that is thought to result from a localised endothelial proliferation of lymphatic vessels resulting in destruction and absorption of bone. The diagnosis of Gorham-Stout syndrome can be made only after first excluding osteolysis from infection, inflammation, endocrine disease, and cancer. The syndrome is rarely seen in the facial skeleton and has a variable prognosis. Many treatments have been advocated but only surgery and radiotherapy have had some success. We present a case of massive osteolysis of the entire mandible, which was reconstructed with a free vascularised fibular graft and bilateral prosthetic replacements of the temporomandibular (TMJ) joints. Four years later the fibular graft had been absorbed requiring further reconstruction with another fibula graft.
巨大性骨溶解（戈勒姆-斯托特综合征）是一种病因不明的罕见病症，被认为是由淋巴管局部内皮细胞增殖导致骨破坏和吸收所致。只有在首先排除感染、炎症、内分泌疾病和癌症引起的骨溶解后，才能做出戈勒姆-斯托特综合征的诊断。该综合征在面部骨骼中很少见，预后不一。人们提出了许多治疗方法，但只有手术和放疗取得了一些成功。我们报告一例全下颌骨巨大性骨溶解病例，采用游离血管化腓骨移植及双侧颞下颌关节假体置换进行重建。四年后，腓骨移植骨被吸收，需要用另一根腓骨移植进行进一步重建。
