Mandibular Gorham-Stout disease: A case report and literature review.

RATIONALE

Gorham-Stout disease (GSD) is characterized by aggressive bone resorption, proliferation of vascular or lymphatic vessels, and soft-tissue swelling. Bones that initially appear normal start to resorb, partially or completely. However, the etiology of GSD is unknown.

PATIENT CONCERNS

A 29-year-old man with a chief complaint of toothache and mobility in the lower right mandible for the previous 1 year.

DIAGNOSES

Gorham-Stout disease (GSD).

INTERVENTIONS

The RANK-ligand inhibitor denosumab was suggested to use to inhibit the development of osteoclasts and slow mandibular resorption. In addition, we proposed resection of the remaining mandible and reconstruction via vascularized bone graft, after resorption of the mandible had become stationary.

OUTCOMES

Regular follow-ups were advised to this patient to monitor the stability of bone resorption prior to any surgical intervention.

LESSONS

We strongly recommend that every attempt should be made for early diagnosis and prompt effective medical and surgical management. The failure to do so results in further complications and poor prognosis.