Hughes Jessica R, Levchenko Vladimir A, Blanksby Stephen J, Mitchell Todd W, Williams Alan, Truscott Roger J W
School of Medicine, University of Wollongong, Wollongong, Australia.
Australian Nuclear Science and Technology Organisation, Lucas Heights, Australia.
Elife. 2015 Mar 11;4:e06003. doi: 10.7554/eLife.06003.
Lipids are critical to cellular function and it is generally accepted that lipid turnover is rapid and dysregulation in turnover results in disease (Dawidowicz 1987; Phillips et al., 2009; Liu et al., 2013). In this study, we present an intriguing counter-example by demonstrating that in the center of the human ocular lens, there is no lipid turnover in fiber cells during the entire human lifespan. This discovery, combined with prior demonstration of pronounced changes in the lens lipid composition over a lifetime (Hughes et al., 2012), suggests that some lipid classes break down in the body over several decades, whereas others are stable. Such substantial changes in lens cell membranes may play a role in the genesis of age-related eye disorders. Whether long-lived lipids are present in other tissues is not yet known, but this may prove to be important in understanding the development of age-related diseases.
脂质对细胞功能至关重要，并且人们普遍认为脂质周转迅速，周转失调会导致疾病（达维多维茨，1987年；菲利普斯等人，2009年；刘等人，2013年）。在本研究中，我们展示了一个有趣的反例，即通过证明在人眼晶状体的中心，纤维细胞在整个人类寿命期间都没有脂质周转。这一发现，结合此前关于晶状体脂质组成在一生中发生显著变化的证明（休斯等人，2012年），表明某些脂质类别在几十年间会在体内分解，而其他脂质则是稳定的。晶状体细胞膜的这种显著变化可能在与年龄相关的眼部疾病的发生中起作用。其他组织中是否存在长寿命脂质尚不清楚，但这可能对理解与年龄相关疾病的发展具有重要意义。
