Chen Jie, Liu Yang, Cai Qing-Qing, Liu Yi-Min, Wang Tong, Zhang Kun, Wang Jing-Feng, Chen Wei-Qing, Huang Hui
From the Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology (JC, YL, TW, KZ, JFW, HH); Sun Yat-sen Memorial Hospital of Sun Yat-sen University (JC, YL, YML, TW, KZ, JFW, HH); Department of Internal Medicine (QQC), Cancer Center; and Department of Biostatistics and Epidemiology (WQC), School of Public Health, Sun Yat-sen University, Guangzhou, China.
Medicine (Baltimore). 2015 Mar;94(10):e627. doi: 10.1097/MD.0000000000000627.
The aims were to access anxiety and type D personality (TDP) in parents of children with leukemia, and to determine the mediating effect of social support and coping style on the relationship between TDP and anxiety. A cross-sectional study was conducted among 231 parents of children with leukemia and 261 parents of children with acute diseases in hospitals. Parents completed questionnaires on anxiety, TDP, social support, coping styles, children's clinical characteristics, and demographic characteristics. Parents of children with leukemia showed higher prevalence of anxiety (64.5% vs 40.2%, P < 0.01) and TDP (44.2% vs 24.1%, P < 0.01) compared with controls. TDP (odds ratio [OR] = 4.34, P < 0.01), lower social support (OR = 1.92, P = 0.02), and less positive coping (OR = 1.87, P = 0.02) were independently associated with anxiety. Parents with TDP showed lower social support and less positive coping, but more negative coping compared with those without. Moreover, multiple mediation analyses revealed that the significant effect of TDP on anxiety was partially mediated by social support and positive coping. In conclusion, anxiety and TDP were highly prevalent in parents of children with leukemia. The predictive factors could be used to identify those parents who are at high risk of anxiety and may also be targets for prevention and intervention.
本研究旨在评估白血病患儿父母的焦虑及D型人格（TDP）状况，并确定社会支持和应对方式在TDP与焦虑关系中的中介作用。对231名白血病患儿的父母及261名患有急性疾病患儿的父母在医院进行了横断面研究。父母们完成了关于焦虑、TDP、社会支持、应对方式、患儿临床特征及人口统计学特征的问卷调查。与对照组相比，白血病患儿的父母焦虑患病率（64.5%对40.2%，P<0.01）和TDP患病率（44.2%对24.1%，P<0.01）更高。TDP（比值比[OR]=4.34，P<0.01）、较低的社会支持（OR=1.92，P=0.02）和较少的积极应对（OR=1.87，P=0.02）与焦虑独立相关。与无TDP的父母相比，有TDP的父母社会支持较低，积极应对较少，但消极应对较多。此外，多重中介分析显示，TDP对焦虑的显著影响部分由社会支持和积极应对介导。总之，焦虑和TDP在白血病患儿父母中高度流行。这些预测因素可用于识别那些焦虑风险高的父母，也可能成为预防和干预的目标。
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