Minami N, Imai Y, Abe K, Munakata M, Sakurada T, Yamamoto M, Yoshida K, Sekino H, Yoshinaga K
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1989 Nov;159(3):185-93. doi: 10.1620/tjem.159.185.
The circadian variation of blood pressure (BP) and heart rate (HR) was examined in 18 normal subjects, 15 patients with essential hypertension treated with beta-blockers and 21 patients with hyperthyroidism. Most of the patients with hyperthyroidism were also treated with beta-blockers. The 24 hr BP was measured with an ambulatory blood pressure monitoring device (UBP-100) every 5 min. A nocturnal fall in BP and HR was observed in the patients with essential hypertension treated with beta-blockers and the patients with mild to moderate hyperthyroidism as well as normal subjects. On the other hand, in patients with severe hyperthyroidism the nocturnal fall was observed in HR alone, and the fall was small in its amplitude. There was a significant negative correlation between triiodothyronine (T3) level and percentage amplitude of the nocturnal fall in systolic BP (n = 21, r = -0.5, p less than 0.01). However, this relation was not significant in diastolic BP and HR. These results indicate that excess thyroid hormone may modulate the circadian variation of BP and HR.
对18名正常受试者、15名接受β受体阻滞剂治疗的原发性高血压患者和21名甲状腺功能亢进症患者的血压（BP）和心率（HR）的昼夜变化进行了研究。大多数甲状腺功能亢进症患者也接受了β受体阻滞剂治疗。使用动态血压监测装置（UBP - 100）每5分钟测量一次24小时血压。在接受β受体阻滞剂治疗的原发性高血压患者、轻度至中度甲状腺功能亢进症患者以及正常受试者中均观察到夜间血压和心率下降。另一方面，在重度甲状腺功能亢进症患者中，仅观察到夜间心率下降，且下降幅度较小。三碘甲状腺原氨酸（T3）水平与夜间收缩压下降幅度百分比之间存在显著负相关（n = 21，r = -0.5，p < 0.01）。然而，这种关系在舒张压和心率方面并不显著。这些结果表明，甲状腺激素过多可能会调节血压和心率的昼夜变化。
