Kohno I, Iwasaki H, Okutani M, Mochizuki Y, Sano S, Satoh Y, Ishihara T, Ishii H, Ijiri H, Komori S, Tamura K
Second Department of Internal Medicine, Yamanashi Medical University, Japan.
Chronobiol Int. 1998 Jul;15(4):337-47. doi: 10.3109/07420529808998694.
We investigated the influence of thyroid hormones on the circadian blood pressure (BP) and heart rate (HR) variations in 12 normotensive subjects and 12 normotensive patients with mild hyperthyroidism. BP and HR were monitored every 30 minutes for 48 h, and electrocardiograms (ECGs) were recorded to measure the RR interval of the ECGs. We analyzed the circadian BP and HR variations, HR variability, and the morning rise in BP and HR. There was no significant difference in the average 24 h BP between groups. HR and pulse pressure were higher in the hyperthyroid group than in the control group. Though the circadian BP pattern was similar in both groups, HR decreased at night in the control group, but not in the hyperthyroid group. Spectrum analysis of the RR interval showed no increase in the high-frequency (HF) component at night in patients with hyperthyroidism. The HR did not show a morning rise in the hyperthyroid group. These findings indicate that the circadian rhythm of HR was not preserved in patients with mild hyperthyroidism. The circadian BP rhythm was similar in normotensive subjects and normotensive patients with mild hyperthyroidism, suggesting that it resulted from factors other than thyroid hormone.
我们研究了甲状腺激素对12名血压正常的受试者和12名轻度甲状腺功能亢进的血压正常患者昼夜血压（BP）和心率（HR）变化的影响。每30分钟监测一次BP和HR，持续48小时，并记录心电图（ECG）以测量心电图的RR间期。我们分析了昼夜BP和HR变化、HR变异性以及BP和HR的晨起升高情况。两组之间的平均24小时BP无显著差异。甲状腺功能亢进组的HR和脉压高于对照组。尽管两组的昼夜BP模式相似，但对照组夜间HR下降，而甲状腺功能亢进组则不然。RR间期的频谱分析显示，甲状腺功能亢进患者夜间高频（HF）成分没有增加。甲状腺功能亢进组的HR没有晨起升高。这些发现表明，轻度甲状腺功能亢进患者的HR昼夜节律未得到保留。血压正常的受试者和轻度甲状腺功能亢进的血压正常患者的昼夜BP节律相似，这表明它是由甲状腺激素以外的因素引起的。
