Synthesis and biological properties of novel triazolopyrimido-pyrimidine-5,8-diones.

The synthesis of novel 1,2,4 triazolo[2,3,4-c,d]pyrimido[4,5-d]pyrimidine derivatives has been described from N-substituted amides of 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-thio-5-pyrimidinecarboxylic acid 1. Amides 1 treated with 80% hydrazine hydrate, followed by aqueous-ethanolic formaldehyde form substituted triazolo[4,3-c]pyrimidines which cyclize in pyridine to triazolopyrimidopyrimidine derivatives 4. Attention has been paid to the synthesis of the 4-arylidenehydrazinopyrimidines 3. Some compounds have been tested for antibacterial and anticancer activities and for action on CNS.