癌症免疫疗法：不断发展的树突状细胞疫苗 - Suppr

Cancer immunotherapy: dendritic-cell vaccines on the move.

作者信息

Sabado Rachel Lubong, Bhardwaj Nina

机构信息

Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

出版信息

Nature. 2015 Mar 19;519(7543):300-1. doi: 10.1038/nature14211. Epub 2015 Mar 11.

DOI:10.1038/nature14211

PMID:25762139

Abstract

摘要

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Cancer immunotherapy: dendritic-cell vaccines on the move.癌症免疫疗法：不断发展的树突状细胞疫苗

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Tetanus shot may improve glioblastoma treatment.破伤风疫苗可能改善胶质母细胞瘤的治疗效果。

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Immunotherapy: Primed for a response.免疫疗法：准备好做出反应。

Nat Rev Cancer. 2015 May;15(5):258-9. doi: 10.1038/nrc3945. Epub 2015 Apr 2.

Cancer immunotherapy: Primed for a response.癌症免疫疗法：蓄势待发。

Nat Rev Drug Discov. 2015 May;14(5):312. doi: 10.1038/nrd4620. Epub 2015 Apr 24.

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.破伤风类毒素和CCL3可改善小鼠及胶质母细胞瘤患者的树突状细胞疫苗。

Nature. 2015 Mar 19;519(7543):366-9. doi: 10.1038/nature14320. Epub 2015 Mar 11.

The development of dendritic cell vaccine-based immunotherapies for glioblastoma.基于树突状细胞疫苗的胶质母细胞瘤免疫疗法的发展。

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Should dendritic cell-based tumor vaccination be incorporated into standard therapy for newly diagnosed glioblastoma patients?基于树突状细胞的肿瘤疫苗接种是否应纳入新诊断胶质母细胞瘤患者的标准治疗中？

Expert Rev Neurother. 2012 Oct;12(10):1173-6. doi: 10.1586/ern.12.107.

Dendritic cell vaccines to combat glioblastoma.用于对抗胶质母细胞瘤的树突状细胞疫苗。

Expert Rev Neurother. 2010 Apr;10(4):483-6. doi: 10.1586/ern.10.26.

Dendritic cell immunotherapy for glioblastoma.胶质母细胞瘤的树突状细胞免疫疗法。

Expert Rev Anticancer Ther. 2014 Jul;14(7):761-3. doi: 10.1586/14737140.2014.921571. Epub 2014 May 21.

A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment.一项使用癌胚抗原脉冲树突状细胞与破伤风类毒素混合并随后进行白细胞介素-2治疗的晚期结直肠癌免疫疗法的I期临床研究。

J Biomed Sci. 2016 Aug 24;23(1):64. doi: 10.1186/s12929-016-0279-7.

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Extracellular vesicles mediated gastric cancer immune response: tumor cell death or immune escape?细胞外囊泡介导的胃癌免疫反应：肿瘤细胞死亡还是免疫逃逸？

Cell Death Dis. 2024 May 30;15(5):377. doi: 10.1038/s41419-024-06758-8.

Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications.免疫细胞衍生的外泌体修饰增强癌症免疫治疗：当前进展和治疗应用。

Exp Mol Med. 2024 Feb;56(1):19-31. doi: 10.1038/s12276-023-01132-8. Epub 2024 Jan 4.

Advancements in dendritic cell vaccination: enhancing efficacy and optimizing combinatorial strategies for the treatment of glioblastoma.树突状细胞疫苗接种的进展：提高治疗胶质母细胞瘤的疗效并优化联合策略

Front Neurol. 2023 Oct 31;14:1271822. doi: 10.3389/fneur.2023.1271822. eCollection 2023.

Recent Advances in Cancer Immunotherapy with a Focus on FDA-Approved Vaccines and Neoantigen-Based Vaccines.癌症免疫疗法的最新进展：聚焦于美国食品药品监督管理局批准的疫苗和基于新抗原的疫苗

Vaccines (Basel). 2023 Oct 25;11(11):1633. doi: 10.3390/vaccines11111633.

Potential of Personalized Dendritic Cell-Based Immunohybridoma Vaccines to Treat Prostate Cancer.基于个性化树突状细胞的免疫杂交瘤疫苗治疗前列腺癌的潜力。

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Modified hollow mesoporous silica nanoparticles as immune adjuvant-nanocarriers for photodynamically enhanced cancer immunotherapy.修饰的中空介孔二氧化硅纳米颗粒作为免疫佐剂-纳米载体用于光动力增强癌症免疫治疗。

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Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles.基于嵌合 RNA 负载树突状细胞衍生细胞外囊泡的癌症新型抗原疫苗接种。

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Biomimetic nanoprobe-augmented triple therapy with photothermal, sonodynamic and checkpoint blockade inhibits tumor growth and metastasis.仿生纳米探针增强的光热、声动力和检查点阻断三重疗法抑制肿瘤生长和转移。

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本文引用的文献

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.破伤风类毒素和CCL3可改善小鼠及胶质母细胞瘤患者的树突状细胞疫苗。

Nature. 2015 Mar 19;519(7543):366-9. doi: 10.1038/nature14320. Epub 2015 Mar 11.

Immunological targeting of cytomegalovirus for glioblastoma therapy.针对胶质母细胞瘤的细胞巨化病毒免疫靶向治疗。

Oncoimmunology. 2014 Jun 25;3:e29289. doi: 10.4161/onci.29289. eCollection 2014.

Chemokines and chemokine receptors: positioning cells for host defense and immunity.趋化因子和趋化因子受体：为宿主防御和免疫定位细胞。

Annu Rev Immunol. 2014;32:659-702. doi: 10.1146/annurev-immunol-032713-120145.

Dendritic-cell-based therapeutic cancer vaccines.基于树突状细胞的治疗性癌症疫苗。

Immunity. 2013 Jul 25;39(1):38-48. doi: 10.1016/j.immuni.2013.07.004.

Low-dose temozolomide before dendritic-cell vaccination reduces (specifically) CD4+CD25++Foxp3+ regulatory T-cells in advanced melanoma patients.低剂量替莫唑胺（temozolomide）在前瞻性黑色素瘤患者树突状细胞疫苗接种前降低（特异性）CD4+CD25++Foxp3+调节性 T 细胞。

J Transl Med. 2013 May 31;11:135. doi: 10.1186/1479-5876-11-135.

Dendritic cell immunotherapy.树突状细胞免疫疗法。

Ann N Y Acad Sci. 2013 May;1284:31-45. doi: 10.1111/nyas.12125.

TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity.树突状细胞 TLR3 诱导的促炎信号传导过程中 TLR4 的结合促进了 IL-10 介导的抗肿瘤免疫抑制。

Cancer Res. 2011 Aug 15;71(16):5467-76. doi: 10.1158/0008-5472.CAN-10-3988. Epub 2011 Jul 5.

Regulatory T cells target chemokine secretion by dendritic cells independently of their capacity to regulate T cell proliferation.调节性 T 细胞靶向树突状细胞的趋化因子分泌，而不依赖于其调节 T 细胞增殖的能力。

J Immunol. 2011 Jun 15;186(12):6807-14. doi: 10.4049/jimmunol.1003265. Epub 2011 May 13.

Sipuleucel-T immunotherapy for castration-resistant prostate cancer.西普利单抗免疫治疗去势抵抗性前列腺癌。

N Engl J Med. 2010 Jul 29;363(5):411-22. doi: 10.1056/NEJMoa1001294.

Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma.转移性黑色素瘤患者中树突状细胞疫苗接种联合CTLA4阻断治疗

Clin Cancer Res. 2009 Oct 1;15(19):6267-76. doi: 10.1158/1078-0432.CCR-09-1254. Epub 2009 Sep 29.

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Cancer immunotherapy: dendritic-cell vaccines on the move.

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