SCH 23390对家兔促甲状腺激素释放激素诱导行为的影响。
Effects of SCH 23390 on thyrotropin-releasing hormone-induced behaviour in rabbits.
作者信息
Popoli P, Caporali M G, Scotti de Carolis A
机构信息
Department of Pharmacology, Istituto Superiore di Sanitù, Rome, Italy.
出版信息
Eur J Pharmacol. 1989 Dec 7;173(2-3):211-3. doi: 10.1016/0014-2999(89)90523-2.
PMID:2576229
Abstract
The influence of the dopamine D-1 receptor antagonist, SCH 23390, on thyrotropin-releasing hormone (TRH)-induced behaviour was assessed in adult male rabbits. SCH 23390 prevented the effects of TRH (100 micrograms i.c.v.), starting at a very low dose (0.01 mg/kg i.v.). This finding seems to indicate that dopamine D-1 receptors are involved in TRH-induced behaviour.
摘要
在成年雄性兔子中评估了多巴胺D-1受体拮抗剂SCH 23390对促甲状腺激素释放激素（TRH）诱导行为的影响。从非常低的剂量（静脉注射0.01毫克/千克）开始，SCH 23390就能阻止TRH（脑室内注射100微克）的作用。这一发现似乎表明多巴胺D-1受体参与了TRH诱导的行为。
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