Barone P, Tucci I, Parashos S A, Chase T N
Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
Eur J Pharmacol. 1988 May 10;149(3):225-32. doi: 10.1016/0014-2999(88)90652-8.
The effect of chronic D-1 dopamine (DA) receptor blockade on D-1 DA receptors and DA-mediated behaviors was studied in rats with unilateral, quinolinic acid-induced striatal lesions. Administration of the selective D-1 antagonist SCH 23390 for 15 days increased D-1 receptor numbers in the unlesioned striatum as indicated by [125I]SCH 23982 binding; ipsilateral turning initiated by the D-2 receptor agonist LY 171555 decreased, while grooming produced by the D-1 receptor agonist SKF 38393 intensified. There was, however, no change in the ability of the D-1 agonist to potentiate D-2 agonist-mediated rotation. The observed behavioral subsensitivity in response to a D-2 agonist may reflect D-1 receptor upregulation and the consequent imbalance of D-1/D-2 receptor interactions in the striatum where these two receptor subtypes appear to play opposite functional roles; potentiation of grooming, primarily a D-1 receptor-mediated behavior, may also reflect the increase in D-1 receptor numbers.
在单侧喹啉酸诱导纹状体损伤的大鼠中，研究了慢性D-1多巴胺（DA）受体阻断对D-1 DA受体和DA介导行为的影响。如[125I]SCH 23982结合所示，给予选择性D-1拮抗剂SCH 23390 15天可增加未损伤纹状体中的D-1受体数量；D-2受体激动剂LY 171555引发的同侧旋转减少，而D-1受体激动剂SKF 38393产生的梳理行为增强。然而，D-1激动剂增强D-2激动剂介导旋转的能力没有变化。观察到的对D-2激动剂反应的行为亚敏感性可能反映了D-1受体上调以及纹状体中D-1/D-2受体相互作用的失衡，在纹状体中这两种受体亚型似乎发挥相反的功能作用；梳理行为增强，主要是一种D-1受体介导的行为，也可能反映了D-1受体数量的增加。
