Volterra G, Borsini F, Meli A
J Pharm Pharmacol. 1988 Sep;40(9):638-41. doi: 10.1111/j.2042-7158.1988.tb05324.x.
The D-2 agonist LY 171555 (0.05, 0.1, 0.2 mg kg-1 s.c.) but not the D-1 agonist SK&F 38393 (5, 10, 20 mg kg-1 s.c.) reduced reserpine-induced hypothermia (RIH) in mice. This effect was antagonized by the D-2 antagonist (-)-sulpiride (50 mg kg-1 i.p.) but not by the D-1 antagonist SCH 23390 (0.1 mg kg-1 s.c.). SK&F 38393 (20 and 1 mg kg-1 s.c.) did not alter the effect of LY 171555 (0.1 and 0.2 mg kg-1) on RIH, but administration of both LY 171555 (0.2 mg kg-1 s.c.) and SK&F 38393 (1 mg kg-1 s.c.) antagonized the reserpine-induced sedation.
D-2激动剂LY 171555（皮下注射0.05、0.1、0.2毫克/千克）可减轻利血平诱导的小鼠体温过低（RIH），而D-1激动剂SK&F 38393（皮下注射5、10、20毫克/千克）则无此作用。D-2拮抗剂（-）-舒必利（腹腔注射50毫克/千克）可拮抗此效应，而D-1拮抗剂SCH 23390（皮下注射0.1毫克/千克）则不能。SK&F 38393（皮下注射20和1毫克/千克）不改变LY 171555（0.1和0.2毫克/千克）对RIH的作用，但同时给予LY 171555（皮下注射0.2毫克/千克）和SK&F 38393（皮下注射1毫克/千克）可拮抗利血平诱导的镇静作用。
