突触前膜进入细胞核！
Presynapses go nuclear!
作者信息
Kravchick Dana O, Jordan Bryen A
机构信息
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA.
出版信息
EMBO J. 2015 Apr 15;34(8):984-6. doi: 10.15252/embj.201591331. Epub 2015 Mar 11.
Abstract
Decades of research has shown that long-term changes in synaptic function ultimately require changes in gene expression.Recent work has focused on nuclear signaling by calcium and protein messengers initiated at postsynaptic sites. In this issue of The EMBO Journal, Ivanova and colleagues show that shuttling of CtBP-1 between presynaptic areas and nuclei regulates gene expression, which reminds us that presynaptic zones should not be ignored when considering synapse-to nucleus signaling.
摘要
数十年的研究表明，突触功能的长期变化最终需要基因表达的改变。最近的研究工作聚焦于由突触后位点引发的钙和蛋白质信使介导的核信号传导。在本期《EMBO杂志》中，伊万诺娃及其同事表明，CtBP-1在突触前区域和细胞核之间的穿梭调节基因表达，这提醒我们，在考虑从突触到细胞核的信号传导时，不应忽视突触前区域。
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