几种抗精神病药、抗抑郁药和单胺摄取阻滞剂对大鼠离体脑组织ATP酶活性及相关氧摄取的影响。

Effects of several neuroleptics, antidepressants and monoamine uptake blockers on ATPase activity and related oxygen uptake in rat brain in vitro.

作者信息

Velasco-Martín A, Garcia J L, Dueñas A

机构信息

Department of Pharmacology, School of Medicine, University of Valladolid, Spain.

出版信息

Methods Find Exp Clin Pharmacol. 1989 Dec;11(12):737-41.

PMID:2576298

Abstract

An experimental trial was conducted to study the effects of phenoxybenzamine, cocaine, carbamazepine, loxapine, clozapine, clothiapine, thiothixene, droperidol, alprazolam, imipramine, maprotiline, dibenzepin, nomifensine, trazodone, mianserin, viloxazine, doxepin and amoxapine on photocolorimetrically rated ATPase activity and on related oxygen uptake, determined by manometrical means, within a concentration range of 0.1-0.001 mM. Phenoxybenzamine, clothiapine and maprotiline at 0.1 mM inhibited sodium-potassium ATPase activity and related QO2 by 30-40%. Loxapine, trazodone, amoxapine and alprazolam at 0.1 mM inhibited sodium-potassium ATPase activity by 25-35%. Imipramine, nomifensine and droperidol at 0.1 mM inhibited QO2 by 20-35%. Cocaine, at all concentrations assayed, inhibited ouabain insensitive ATPase. The remaining drugs did not produce significant modifications.

摘要

进行了一项实验性试验，以研究苯氧苄胺、可卡因、卡马西平、洛沙平、氯氮平、氯噻平、硫利达嗪、氟哌利多、阿普唑仑、丙咪嗪、马普替林、二苯并氮䓬、诺米芬辛、曲唑酮、米安色林、维洛沙嗪、多塞平和阿莫沙平在0.1 - 0.001 mM浓度范围内对光比色法测定的ATP酶活性以及通过压力计法测定的相关氧摄取的影响。0.1 mM的苯氧苄胺、氯噻平和马普替林抑制钠钾ATP酶活性及相关的QO2达30 - 40%。0.1 mM的洛沙平、曲唑酮、阿莫沙平和阿普唑仑抑制钠钾ATP酶活性达25 - 35%。0.1 mM的丙咪嗪、诺米芬辛和氟哌利多抑制QO2达20 - 35%。在所测定的所有浓度下，可卡因均抑制哇巴因不敏感的ATP酶。其余药物未产生显著变化。