Alpogan Oksan, Donmez Emin Erhan, Vural Fisun, Balık Ayşe Özlem
Department of Ophthalmology, Health Sciences University, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Health Sciences University, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Transgend Health. 2023 Jul 28;8(4):363-370. doi: 10.1089/trgh.2022.0061. eCollection 2023 Aug.
This study aimed to evaluate the relationship between androgens and the retinal thickness by comparing the macular thickness (MT), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness of female-to-male transgender men (TGM), women with polycystic ovary syndrome (PCOS), and cisgender women (CW).
Thirty-four eyes of 34 TGM, 34 eyes of 34 women with PCOS, and 45 eyes of 45 CW were evaluated by optical coherence tomography. One-way analysis of variance and body mass index (BMI)-adjusted one-way analysis of covariance were conducted to test the differences between groups for statistical evaluation.
The parafoveal MT in TGM was significantly higher than women with PCOS and CW (<0.001 and =0.022, respectively). After adjusting for BMI, the perifoveal MT in TGM was significantly higher than women with PCOS and CW (=0.041 and =0.021, respectively). The nasal RNFL thickness in TGM was significantly higher than women with PCOS and CW (=0.021 and =0.009, respectively). The means of average and inferior RNFL, fovea, and the mean of all GCC values were higher in the TGM group than women with PCOS and CW, but these results were not statistically significant.
In this study, there was a significant difference between the TGM group and the CW group for the thickness of the nasal RNFL and parafoveal and perifoveal macular area. Androgens may have the potential to increase retinal thickness in TGM; however, there is a need for validation in larger study groups. Clinical Trial Registration Number: HNEAH-KAEK 2021/4.
本研究旨在通过比较女性至男性跨性别男性（TGM）、多囊卵巢综合征（PCOS）女性和顺性别女性（CW）的黄斑厚度（MT）、视网膜神经纤维层（RNFL）和神经节细胞复合体（GCC）厚度，评估雄激素与视网膜厚度之间的关系。
通过光学相干断层扫描对34名TGM的34只眼、34名PCOS女性的34只眼和45名CW的45只眼进行评估。进行单因素方差分析和体重指数（BMI）调整后的单因素协方差分析，以检验组间差异进行统计学评估。
TGM的旁中心凹MT显著高于PCOS女性和CW（分别为<0.001和=0.022）。调整BMI后，TGM的中心凹周围MT显著高于PCOS女性和CW（分别为=0.041和=0.021）。TGM的鼻侧RNFL厚度显著高于PCOS女性和CW（分别为=0.021和=0.009）。TGM组的平均和下方RNFL、黄斑中心凹以及所有GCC值的平均值均高于PCOS女性和CW组，但这些结果无统计学意义。
在本研究中，TGM组与CW组在鼻侧RNFL以及旁中心凹和中心凹周围黄斑区域的厚度存在显著差异。雄激素可能有增加TGM视网膜厚度的潜力；然而，需要在更大的研究组中进行验证。临床试验注册号：HNEAH-KAEK 2021/4。
