Théry Clotilde
Institut Curie INSERM U932, Paris France.
F1000 Biol Rep. 2011;3:15. doi: 10.3410/B3-15. Epub 2011 Jul 1.
Exosomes are small membrane vesicles of endocytic origin secreted by most cell types, and are thought to play important roles in intercellular communications. Although exosomes were originally described in 1983, interest in these vesicles has really increased dramatically in the last 3 years, after the finding that they contain mRNA and microRNA. This discovery sparked renewed interest for the general field of membrane vesicles involved in intercellular communications, and research on these structures has grown exponentially over the last few years, probing their composition and function, as well as their potential value as biomarkers.
外泌体是大多数细胞类型分泌的内吞起源的小膜泡，被认为在细胞间通讯中发挥重要作用。尽管外泌体最初于1983年被描述，但在发现它们含有mRNA和微小RNA之后，对这些小泡的兴趣在过去3年中急剧增加。这一发现激发了人们对参与细胞间通讯的膜泡这一广泛领域的新兴趣，并且在过去几年中，对这些结构的研究呈指数级增长，探究它们的组成和功能，以及它们作为生物标志物的潜在价值。
