莱索托罗马地区通过实验室检测值确定的乙肝病毒/艾滋病毒合并感染情况
Occurrence of HBV/HIV coinfection by laboratory values in Roma, Lesotho.
作者信息
Mugomeri Eltony, Senauoane Mamakoli Blandina, Ruhanya Vurayai, Chin'ombe Nyasha, Nyandoro George
机构信息
MTech, Department of Pharmacy, National University of Lesotho, Maseru, Lesotho.
BSc, Department of Nursing, National University of Lesotho, Maseru, Lesotho.
出版信息
Germs. 2015 Mar 2;5(1):8-11. doi: 10.11599/germs.2015.1065. eCollection 2015 Mar.
OBJECTIVE
This study was an assessment of the coinfection status of patients with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in Lesotho, and this has been rarely reported.
METHODS
This was a retrospective study, in a laboratory setting, on HBV/HIV coinfection among 304 HIV-positive patients who were screened for HBsAg in St Joseph's Hospital records between March 2011 and December 2013. Demographic characteristics, HIV status, indications for HBsAg screening, HBsAg results and liver function test results including alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase were reviewed from the patient and laboratory registers.
RESULTS
In this study 10.5% of 304 HIV-positive patients had HBV/HIV coinfection. With respect to gender, males had a significantly higher (p=0.048) rate of HBV/HIV coinfection in this study. Increased levels of ALT (p=0.013) and AST (p=0.014) were significantly associated with HBV/HIV coinfection status.
CONCLUSION
Gender and liver function tests are important predictors for HBV/HIV coinfection. Screening for HBV coinfection in HIV-positive patients is recommended.
目的
本研究旨在评估莱索托人类免疫缺陷病毒（HIV）和乙型肝炎病毒（HBV）合并感染患者的状况，而这方面的报道很少。
方法
这是一项回顾性研究，在实验室环境中，对2011年3月至2013年12月期间在圣约瑟夫医院记录中接受HBsAg筛查的304例HIV阳性患者中的HBV/HIV合并感染情况进行研究。从患者和实验室登记册中回顾了人口统计学特征、HIV状况、HBsAg筛查指征、HBsAg结果以及肝功能测试结果，包括丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和碱性磷酸酶。
结果
在本研究中，304例HIV阳性患者中有10.5%患有HBV/HIV合并感染。在性别方面，男性在本研究中的HBV/HIV合并感染率显著更高（p=0.048）。ALT（p=0.013）和AST（p=0.014）水平升高与HBV/HIV合并感染状况显著相关。
结论
性别和肝功能测试是HBV/HIV合并感染的重要预测因素。建议对HIV阳性患者进行HBV合并感染筛查。
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