Joo Nam-Seok, Yang Sung-Won, Song Byeng Chun, Yeum Kyung-Jin
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon 443-781, Korea.
Division of Food and Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju-si, Chungcheonbuk-do 380-701, Korea.
Nutrients. 2015 Mar 10;7(3):1716-27. doi: 10.3390/nu7031716.
The association of high vitamin A intake and low bone mineral density (BMD) is still controversial. To determine the association of dietary vitamin A intake and serum 25-hydroxyvitamin D (25(OH)D) concentration with BMD, a total of 6481 subjects (2907 men and 3574 women) aged ≥50 years from the Korean National Health and Nutrition Examination Survey (2008-2011) were divided into groups according to dietary vitamin A intake (tertiles) and serum 25(OH)D (<50, 50-75, >75 nmol/L), and evaluated for BMD after adjusting for relevant variables. Mean dietary vitamin A intakes were 737 and 600 μg RE (Retinol Equivalents) in men and women, respectively. Total hip and femoral neck BMD in men and lumbar spine BMD in women were both positively correlated with dietary vitamin A intake in subjects with serum 25(OH)D >75 nmol/L. Among men with serum 25(OH)D <50 nmol/L, both the top (mean 1353 μg RE) and bottom (mean 218 μg RE) tertiles of dietary vitamin A intake had lower BMD than the middle group (mean 577 μg RE). In this population, BMD was the highest among men and women with serum 25(OH)D = 50-75 nmol/L and that there were no differences in BMD by vitamin A intake in these vitamin D adequate groups. This cross-sectional study indicates that vitamin A intake does not affect bone mineral density as long as the serum 25(OH)D concentration is maintained in the moderate level of 50-75 nmol/L.
高维生素A摄入量与低骨矿物质密度（BMD）之间的关联仍存在争议。为了确定膳食维生素A摄入量和血清25-羟基维生素D（25(OH)D）浓度与BMD之间的关联，来自韩国国家健康与营养检查调查（2008 - 2011年）的6481名年龄≥50岁的受试者（2907名男性和3574名女性）根据膳食维生素A摄入量（三分位数）和血清25(OH)D（<50、50 - 75、>75 nmol/L）进行分组，并在调整相关变量后评估BMD。男性和女性的平均膳食维生素A摄入量分别为737和600 μg视黄醇当量（RE）。在血清25(OH)D>75 nmol/L的受试者中，男性的全髋和股骨颈BMD以及女性的腰椎BMD均与膳食维生素A摄入量呈正相关。在血清25(OH)D<50 nmol/L的男性中，膳食维生素A摄入量最高（平均1353 μg RE）和最低（平均218 μg RE）的三分位数组的BMD均低于中间组（平均577 μg RE）。在该人群中，血清25(OH)D = 50 - 75 nmol/L的男性和女性的BMD最高，并且在这些维生素D充足的组中，BMD在维生素A摄入量方面没有差异。这项横断面研究表明，只要血清25(OH)D浓度维持在50 - 75 nmol/L的适度水平，维生素A摄入量就不会影响骨矿物质密度。
