Yeum Kyung-Jin, Song Byeng Chun, Joo Nam-Seok
Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju-si 27478, Korea.
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon-si 16499, Korea.
Int J Environ Res Public Health. 2016 Feb 2;13(2):184. doi: 10.3390/ijerph13020184.
A significant decline of serum 25-hydroxyvitamin D concentration [25(OH)D] with increasing latitude has been reported only for Caucasians. To determine the association between serum 25(OH)D and geographic location and its impact on bone mineral density (BMD) in an Asian population, a total of 17,508 subjects (8910 men and 8598 women) from the 2008-2010 Korea National Health and Nutrition Examination Survey (KNHANES) were stratified into four age groups and analyzed for 25(OH)D and BMD according to geographic location (South, 33° N-35° N; Middle, 36° N; North, 37° N-38° N). Mean 25(OH)D were 47.7 and 41.2 nmol/L; calcium intake, 564.9 & 442.3 mg/d; femoral neck BMD, 0.829 & 0.721 g/cm²; and lumbar spine BMD, 0.960 & 0.918 g/cm² for men and women, respectively. Both men and women living in the South had significantly higher 25(OH)D and femoral neck BMD for those ≥50 years old. Lumbar spine BMD was significantly higher in men ≥50 years old, and for women 10-29 & 50-69 years old living in the South. A 1 or 2 degree difference in latitude has a significant effect on serum 25(OH)D and BMD in this low vitamin D status population. Thus, consideration of geographic location for a recommendation of vitamin D intake may be necessary.
据报道，仅在白种人中，血清25-羟基维生素D浓度[25(OH)D]会随着纬度升高而显著下降。为了确定亚洲人群中血清25(OH)D与地理位置之间的关联及其对骨密度（BMD）的影响，我们将2008 - 2010年韩国国民健康与营养检查调查（KNHANES）中的17508名受试者（8910名男性和8598名女性）分为四个年龄组，并根据地理位置（南部，北纬33° - 35°；中部，北纬36°；北部，北纬37° - 38°）分析了25(OH)D和BMD。男性和女性的平均25(OH)D分别为47.7和41.2 nmol/L；钙摄入量分别为564.9和442.3 mg/d；股骨颈BMD分别为0.829和0.721 g/cm²；腰椎BMD分别为0.960和0.918 g/cm²。对于50岁及以上居住在南部的男性和女性，其25(OH)D和股骨颈BMD均显著更高。50岁及以上男性以及居住在南部的10 - 29岁和50 - 69岁女性的腰椎BMD显著更高。在这个维生素D水平较低的人群中，纬度相差1度或2度对血清25(OH)D和BMD有显著影响。因此，在推荐维生素D摄入量时可能有必要考虑地理位置。
